Protein Summary
Adapter molecule functioning in neural development. May regulate SIAH1 activity. The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. [provided by RefSeq, Jan 2017]
- ENST00000371230
- ENSP00000360274
- ENSG00000173406
- ENST00000371231
- ENSP00000360275
- ENST00000371236
- ENSP00000360280
- ENST00000414851
- ENSP00000387581
- ENST00000420954
- ENSP00000395296
- SCA37
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 1 | ||
biological process | 0.91 | ||
hub protein | 0.88 | ||
phenotype | 0.85 | ||
kinase | 0.82 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.14 (req: < 5)
Gene RIFs: 40 (req: <= 3)
Antibodies: 489 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.14 (req: >= 5)
Gene RIFs: 40 (req: > 3)
Antibodies: 489 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0