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Tbio
DAB1
Disabled homolog 1

Protein Summary
Description
Adapter molecule functioning in neural development. May regulate SIAH1 activity. The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371230
  • ENSP00000360274
  • ENSG00000173406
  • ENST00000371231
  • ENSP00000360275
  • ENST00000371236
  • ENSP00000360280
  • ENST00000414851
  • ENSP00000387581
  • ENST00000420954
  • ENSP00000395296

Symbol
  • SCA37
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
biological process
0.91
hub protein
0.88
phenotype
0.85
kinase
0.82


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.14   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 489   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.14   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 489   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0