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Tdark
USP17L22
Ubiquitin carboxyl-terminal hydrolase 17-like protein 22

Protein Classes
Protein Summary
Description
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000511280
  • ENSP00000423115
  • ENSG00000248933
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.58
cell line
0.43
tissue
0.43
biological process
0.4
molecular function
0.38


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.01   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 3   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.01   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 3   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Ub-specific processing proteases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Ub-specific processing proteases
Protein-Protein Interactions (21)
1 – 10 of 21
USP17L11
Tdark
Family: Enzyme
Novelty: 122
Score: 0.913
Data Source: STRINGDB
USP17L20
Tdark
Family: Enzyme
Novelty: 6
Score: 0.908
Data Source: STRINGDB
USP17L2
Tbio
Family: Enzyme
Novelty: 0.06585454
Score: 0.906
Data Source: STRINGDB
USP17L19
Tdark
Family: Enzyme
Score: 0.905
Data Source: STRINGDB
USP17L10
Tdark
Family: Enzyme
Score: 0.903
Data Source: STRINGDB
USP17L21
Tdark
Family: Enzyme
Score: 0.902
Data Source: STRINGDB
USP17L5
Tdark
Family: Enzyme
Novelty: 31.00671141
Score: 0.902
Data Source: STRINGDB
USP17L18
Tdark
Family: Enzyme
Novelty: 122
Score: 0.902
Data Source: STRINGDB
USP17L12
Tdark
Family: Enzyme
Novelty: 11
Score: 0.902
Data Source: STRINGDB
USP17L4
Tdark
Family: Enzyme
Novelty: 11.52
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.01

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer