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Tbio
CYTIP
Cytohesin-interacting protein

Protein Summary
Description
By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm. The protein encoded by this gene contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal, but does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells. The encoded protein modulates the activation of ARF genes by CYTH1. This protein interacts with CYTH1 and SNX27 proteins and may act to sequester CYTH1 protein in the cytoplasm.[provided by RefSeq, Aug 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264192
  • ENSP00000264192
  • ENSG00000115165

Symbol
  • PSCDBP
  • HE
  • B3-1
  • CASP
  • CYBR
  • CYTHIP
  • PSCDBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.8
transcription factor perturbation
0.68
tissue sample
0.66
co-expressed gene
0.65
kinase perturbation
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.55   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.55   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (80)
CYTH1
Tbio
Novelty:  0.00635156
p_int:  0.999999995
p_ni:  5e-9
Score:  0.884
Data Source:  BioPlex,STRINGDB
CYTH3
Tbio
Novelty:  0.00940752
p_int:  0.999999678
p_ni:  3.21e-7
p_wrong:  1e-9
Score:  0.782
Data Source:  BioPlex,STRINGDB
CYTH2
Tbio
Novelty:  0.03560664
p_int:  0.99999907
p_ni:  9.3e-7
Score:  0.47
Data Source:  BioPlex,STRINGDB
ABRAXAS2
Tbio
Novelty:  0.20430604
p_int:  0.942290917
p_ni:  0.057709083
Score:  0.159
Data Source:  BioPlex,STRINGDB
EDEM2
Tbio
Family:  Enzyme
Novelty:  0.1180208
p_int:  0.85032018
p_ni:  0.149679045
p_wrong:  7.76e-7
Score:  0.183
Data Source:  BioPlex,STRINGDB
HBB
Tbio
Novelty:  0.00049683
p_int:  0.827784572
p_ni:  0.057955309
p_wrong:  0.11426012
Score:  0.223
Data Source:  BioPlex,STRINGDB
ERAL1
Tbio
Family:  Enzyme
Novelty:  0.01695998
Score:  0.831
Data Source:  STRINGDB
SNX27
Tbio
Novelty:  0.02419724
Score:  0.762
Data Source:  STRINGDB
DGKZ
Tchem
Family:  Enzyme
Novelty:  0.01312044
Score:  0.725
Data Source:  STRINGDB
SERPINB3
Tbio
Novelty:  0.00325244
Score:  0.719
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (31)
Find Similar Targets
Items per page:
1 – 5 of 31
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Amplification and Expansion of Oncogenic Pathways as Metastatic Traits
WikiPathways
Amplification and Expansion of Oncogenic Pathways as Metastatic Traits
WikiPathways
Amplification and Expansion of Oncogenic Pathways as Metastatic Traits
WikiPathways
Amplification and Expansion of Oncogenic Pathways as Metastatic Traits
WikiPathways
Robo4 and VEGF Signaling Pathways Crosstalk
Name
Explore in Pharos
Explore in Source
Amplification and Expansion of Oncogenic Pathways as Metastatic Traits
Amplification and Expansion of Oncogenic Pathways as Metastatic Traits
Amplification and Expansion of Oncogenic Pathways as Metastatic Traits
Amplification and Expansion of Oncogenic Pathways as Metastatic Traits
Robo4 and VEGF Signaling Pathways Crosstalk
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist circumference
1
3
3
89.1
BMI-adjusted waist-hip ratio
6
3
8
88.4
BMI-adjusted waist circumference
1
3
3
87.9
waist-hip ratio
3
3
5
87
birth weight
1
2
2
79.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist circumference
3
89.1
BMI-adjusted waist-hip ratio
8
88.4
BMI-adjusted waist circumference
3
87.9
waist-hip ratio
5
87
birth weight
2
79.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytohesin 1 interacting protein
VGNC:158
459673
Mouse
MGI:2183535
227929
Rat
RGD:1307990
311047
Dog
cytohesin 1 interacting protein
VGNC:50297
488360
Horse
cytohesin 1 interacting protein
VGNC:50473
100059499
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytohesin 1 interacting protein
Mouse
Rat
Dog
cytohesin 1 interacting protein
Horse
cytohesin 1 interacting protein
Publication Statistics
PubMed Score 57.55
PubMed score by year
PubTator Score 81.78
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title