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Tbio
CYTH4
Cytohesin-4

Protein Summary
Description
Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP. This gene encodes a member of the PSCD family of proteins, which have an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family function as GEPs for ADP-ribosylation factors (ARFs), which are guanine nucleotide-binding proteins involved in vesicular trafficking pathways. This protein exhibits GEP activity in vitro with ARF1 and ARF5, but is inactive with ARF6. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248901
  • ENSP00000248901
  • ENSG00000100055

Symbol
  • CYT4
  • PSCD4
  • CYT4
  • PSCD4
  • DJ63G5.1
  • cytohesin-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.62
protein domain
0.58
cell line
0.56
gene perturbation
0.56
transcription factor
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.5   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.5   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (122)
CCDC120
Tbio
Novelty:  0.48574876
p_int:  0.999999993
p_ni:  5e-9
p_wrong:  2e-9
Score:  0.171
Data Source:  BioPlex,STRINGDB
PROX1
Tbio
Family:  TF
Novelty:  0.00349114
p_int:  0.999999763
p_ni:  1.83e-7
p_wrong:  5.4e-8
Data Source:  BioPlex
CWC25
Tdark
Novelty:  0.13727856
p_int:  0.999999095
p_ni:  5e-9
p_wrong:  9e-7
Data Source:  BioPlex
TUFT1
Tbio
Novelty:  0.01999031
p_int:  0.99999705
p_ni:  0.00000295
Data Source:  BioPlex
FRMD4A
Tbio
Novelty:  0.10960581
p_int:  0.99998881
p_ni:  0.000007263
p_wrong:  0.000003928
Data Source:  BioPlex
TRAF7
Tbio
Family:  Enzyme
Novelty:  0.02437761
p_int:  0.999980979
p_ni:  0.000019021
Data Source:  BioPlex
MIS18A
Tbio
Novelty:  0.08143008
p_int:  0.999257778
p_ni:  0.000735777
p_wrong:  0.000006445
Score:  0.206
Data Source:  BioPlex,STRINGDB
OFD1
Tbio
Novelty:  0.01032841
p_int:  0.987777532
p_ni:  0.012221864
p_wrong:  6.04e-7
Data Source:  BioPlex
CCDC88A
Tbio
Novelty:  0.01077253
p_int:  0.984721745
p_ni:  0.015278255
Data Source:  BioPlex
IPCEF1
Tbio
Novelty:  0.3372832
p_int:  0.980021879
p_ni:  0.006303681
p_wrong:  0.01367444
Score:  0.355
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.4
79.9
autoimmune thyroid disease
1
1
0
1.1
79.8
Thyroid preparation use measurement
1
1
1
78.4
1
1
0
1.2
72.3
mean platelet volume
2
1
2
60.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
79.9
autoimmune thyroid disease
0
1.1
79.8
Thyroid preparation use measurement
1
78.4
0
1.2
72.3
mean platelet volume
2
60.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytohesin 4
VGNC:12838
458809
Macaque
cytohesin 4
696837
Mouse
MGI:2441702
72318
Rat
RGD:1564842
500906
Dog
cytohesin 4
VGNC:50296
481270
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytohesin 4
Macaque
cytohesin 4
Mouse
Rat
Dog
cytohesin 4
Publication Statistics
PubMed Score 16.50
PubMed score by year
PubTator Score 10.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title