You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CYTH3
Cytohesin-3

Protein Summary
Description
Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Play a role in the epithelial polarization (By similarity). This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in ad ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350796
  • ENSP00000297044
  • ENSG00000008256
  • ENST00000396741
  • ENSP00000379967

Symbol
  • ARNO3
  • GRP1
  • PSCD3
  • GRP1
  • ARNO3
  • PSCD3
  • cytohesin-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.77
transcription factor
0.73
cell type or tissue
0.65
histone modification site profile
0.62
kinase perturbation
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.76   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.76   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
CNKSR1
Tchem
Family:  Enzyme
Novelty:  0.06710697
p_int:  0.999999975
p_ni:  2.3e-8
p_wrong:  2e-9
Score:  0.544
Data Source:  BioPlex,STRINGDB
IPCEF1
Tbio
Novelty:  0.3372832
p_int:  0.999999937
p_ni:  6.2e-8
p_wrong:  1e-9
Score:  0.331
Data Source:  BioPlex,STRINGDB
CYTIP
Tbio
Novelty:  0.01965202
p_int:  0.999999678
p_ni:  3.21e-7
p_wrong:  1e-9
Score:  0.782
Data Source:  BioPlex,STRINGDB
CCDC120
Tbio
Novelty:  0.48574876
p_int:  0.999972135
p_ni:  0.000027865
Score:  0.275
Data Source:  BioPlex,STRINGDB
INAVA
Tbio
Novelty:  0.19311978
p_int:  0.999970809
p_ni:  0.000029182
p_wrong:  9e-9
Score:  0.316
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999883435
p_ni:  0.000116565
Data Source:  BioPlex
FOSL2
Tbio
Family:  TF
Novelty:  0.00375452
p_int:  0.997913085
p_ni:  0.002086806
p_wrong:  1.1e-7
Score:  0.172
Data Source:  BioPlex,STRINGDB
GPS2
Tbio
Novelty:  0.00986158
p_int:  0.997123819
p_ni:  0.002851827
p_wrong:  0.000024355
Data Source:  BioPlex
IFI35
Tbio
Novelty:  0.04309126
p_int:  0.895699573
p_ni:  0.104300426
p_wrong:  1e-9
Score:  0.211
Data Source:  BioPlex,STRINGDB
OIP5
Tbio
Novelty:  0.02546471
p_int:  0.78681796
p_ni:  0.213141263
p_wrong:  0.000040777
Score:  0.193
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (77)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
1
1
1
52.6
neutrophil percentage of leukocytes
1
1
1
32.3
reticulocyte measurement
1
1
1
21.1
C-reactive protein measurement
2
1
2
2.6
Agents acting on the renin-angiotensin system use measurement
1
1
1
2.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
1
52.6
neutrophil percentage of leukocytes
1
32.3
reticulocyte measurement
1
21.1
C-reactive protein measurement
2
2.6
Agents acting on the renin-angiotensin system use measurement
1
2.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytohesin 3
VGNC:13643
100614767
Macaque
cytohesin 3
717713
Mouse
MGI:1335107
19159
Rat
RGD:620399
116693
Horse
cytohesin 3
VGNC:51122
100061994
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytohesin 3
Macaque
cytohesin 3
Mouse
Rat
Horse
cytohesin 3
Publication Statistics
PubMed Score 119.76
PubMed score by year
PubTator Score 57.79
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title