Protein Summary
Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (PubMed:17398095). Involved in neurite growth (By similarity). The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, A ...more
- ENST00000452733
- ENSP00000408236
- ENSG00000105443
- ENST00000641098
- ENSP00000493357
- ARNO
- PSCD2
- PSCD2L
- ARNO
- CTS18
- PSCD2
- SEC7L
- PSCD2L
- CTS18.1
- Sec7p-L
- Sec7p-like
- cytohesin-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cell type or tissue | 0.77 | ||
histone modification site profile | 0.76 | ||
transcription factor | 0.67 | ||
hub protein | 0.63 | ||
cell line | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.12 (req: < 5)
Gene RIFs: 28 (req: <= 3)
Antibodies: 266 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.12 (req: >= 5)
Gene RIFs: 28 (req: > 3)
Antibodies: 266 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (66)
CNKSR1
Family: Enzyme
Novelty: 0.06710697
p_int: 0.999999999
Score: 0.364
Data Source: BioPlex,STRINGDB
IPCEF1
Novelty: 0.3372832
p_int: 0.999999997
p_ni: 3e-9
Score: 0.976
Data Source: BioPlex,STRINGDB
INAVA
Novelty: 0.19311978
p_int: 0.999999299
p_ni: 7.01e-7
Score: 0.316
Data Source: BioPlex,STRINGDB
CCDC120
Novelty: 0.48574876
p_int: 0.999999092
p_ni: 9.08e-7
Score: 0.752
Data Source: BioPlex,STRINGDB
CYTIP
Novelty: 0.01965202
p_int: 0.99999907
p_ni: 9.3e-7
Score: 0.47
Data Source: BioPlex,STRINGDB
FOSL2
Family: TF
Novelty: 0.00375452
p_int: 0.995967825
p_ni: 0.004032175
Score: 0.187
Data Source: BioPlex,STRINGDB
CCDC40
Novelty: 0.06726469
p_int: 0.981680872
p_ni: 0.018319128
Score: 0.165
Data Source: BioPlex,STRINGDB
ATP5IF1
Family: Enzyme
Novelty: 0.01272196
p_int: 0.918484527
p_ni: 0.081505979
p_wrong: 0.000009494
Data Source: BioPlex
Nearest Tclin Targets
Pathways (9)
Reactome (4)
KEGG (2)
PathwayCommons (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Intra-Golgi and retrograde Golgi-to-ER traffic | ||||
Reactome | Intra-Golgi traffic | ||||
Reactome | Membrane Trafficking | ||||
Reactome | Vesicle-mediated transport | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Intra-Golgi and retrograde Golgi-to-ER traffic | ||||
Intra-Golgi traffic | ||||
Membrane Trafficking | ||||
Vesicle-mediated transport | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (3)
Components (8)
Processes (3)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mathematical ability | 2 | 1 | 2 | 31.4 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mathematical ability | 2 | 31.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cytohesin 2 | VGNC:10978 | 746757 | |||||
Macaque | cytohesin 2 | 718682 | ||||||
Mouse | MGI:1334255 | 19158 | ||||||
Rat | RGD:620398 | 116692 | ||||||
Dog | cytohesin 2 | VGNC:50306 | 476423 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | cytohesin 2 | |||||
Macaque | cytohesin 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cytohesin 2 | |||||
Publication Statistics
PubMed Score 22.12
PubMed score by year
PubTator Score 143.01
PubTator score by year
Related Publications
Text Mined References (59)
GeneRif Annotations (28)
Items per page:
0 of 0
PMID | Year | Title |
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