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Tbio
CYTH2
Cytohesin-2

Protein Summary
Description
Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (PubMed:17398095). Involved in neurite growth (By similarity). The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, A ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000452733
  • ENSP00000408236
  • ENSG00000105443
  • ENST00000641098
  • ENSP00000493357

Symbol
  • ARNO
  • PSCD2
  • PSCD2L
  • ARNO
  • CTS18
  • PSCD2
  • SEC7L
  • PSCD2L
  • CTS18.1
  • Sec7p-L
  • Sec7p-like
  • cytohesin-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.77
histone modification site profile
0.76
transcription factor
0.67
hub protein
0.63
cell line
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.12   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 266   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.12   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
CNKSR1
Tchem
Family:  Enzyme
Novelty:  0.06710697
p_int:  0.999999999
Score:  0.364
Data Source:  BioPlex,STRINGDB
IPCEF1
Tbio
Novelty:  0.3372832
p_int:  0.999999997
p_ni:  3e-9
Score:  0.976
Data Source:  BioPlex,STRINGDB
INAVA
Tbio
Novelty:  0.19311978
p_int:  0.999999299
p_ni:  7.01e-7
Score:  0.316
Data Source:  BioPlex,STRINGDB
CCDC120
Tbio
Novelty:  0.48574876
p_int:  0.999999092
p_ni:  9.08e-7
Score:  0.752
Data Source:  BioPlex,STRINGDB
CYTIP
Tbio
Novelty:  0.01965202
p_int:  0.99999907
p_ni:  9.3e-7
Score:  0.47
Data Source:  BioPlex,STRINGDB
STRIP2
Tbio
Novelty:  0.19321125
p_int:  0.99995925
p_ni:  0.00004075
Data Source:  BioPlex
FOSL2
Tbio
Family:  TF
Novelty:  0.00375452
p_int:  0.995967825
p_ni:  0.004032175
Score:  0.187
Data Source:  BioPlex,STRINGDB
CCDC40
Tbio
Novelty:  0.06726469
p_int:  0.981680872
p_ni:  0.018319128
Score:  0.165
Data Source:  BioPlex,STRINGDB
ATP5IF1
Tbio
Family:  Enzyme
Novelty:  0.01272196
p_int:  0.918484527
p_ni:  0.081505979
p_wrong:  0.000009494
Data Source:  BioPlex
ARF1
Tchem
Family:  Enzyme
Novelty:  0.00208554
Score:  0.999
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytohesin 2
VGNC:10978
746757
Macaque
cytohesin 2
718682
Mouse
MGI:1334255
19158
Rat
RGD:620398
116692
Dog
cytohesin 2
VGNC:50306
476423
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytohesin 2
Macaque
cytohesin 2
Mouse
Rat
Dog
cytohesin 2
Publication Statistics
PubMed Score 22.12
PubMed score by year
PubTator Score 143.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title