Tbio CYTH2 Cytohesin-2

Protein Summary

Description

Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (PubMed:17398095). Involved in neurite growth (By similarity). The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Uniprot Accession IDs

• Q99418
• A8K8P0
• Q8IXY9
• Q92958

Gene Name

• CYTH2

Ensembl ID

• ENST00000452733
• ENSP00000408236
• ENSG00000105443
• ENST00000641098
• ENSP00000493357

Symbol

• ARNO
• PSCD2
• PSCD2L
• ARNO
• CTS18
• PSCD2
• SEC7L
• PSCD2L
• CTS18.1
• Sec7p-L
• Sec7p-like
• cytohesin-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.77
histone modification site profile	0.76
transcription factor	0.67
hub protein	0.63
cell line	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.12   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 266   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.12   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (66)

Explore Interacting Targets

1 – 10 of 66

• See Interactions on String-DB

CNKSR1

Tchem

Family:  Enzyme

Novelty:  0.06710697

p_int:  0.999999999

Score:  0.364

Data Source:  BioPlex,STRINGDB

IPCEF1

Tbio

Novelty:  0.3372832

p_int:  0.999999997

p_ni:  3e-9

Score:  0.976

Data Source:  BioPlex,STRINGDB

INAVA

Tbio

Novelty:  0.19311978

p_int:  0.999999299

p_ni:  7.01e-7

Score:  0.316

Data Source:  BioPlex,STRINGDB

CCDC120

Tbio

Novelty:  0.48574876

p_int:  0.999999092

p_ni:  9.08e-7

Score:  0.752

Data Source:  BioPlex,STRINGDB

CYTIP

Tbio

Novelty:  0.01965202

p_int:  0.99999907

p_ni:  9.3e-7

Score:  0.47

Data Source:  BioPlex,STRINGDB

STRIP2

Tbio

Novelty:  0.19321125

p_int:  0.99995925

p_ni:  0.00004075

Data Source:  BioPlex

FOSL2

Tbio

Family:  TF

Novelty:  0.00375452

p_int:  0.995967825

p_ni:  0.004032175

Score:  0.187

Data Source:  BioPlex,STRINGDB

CCDC40

Tbio

Novelty:  0.06726469

p_int:  0.981680872

p_ni:  0.018319128

Score:  0.165

Data Source:  BioPlex,STRINGDB

ATP5IF1

Tbio

Family:  Enzyme

Novelty:  0.01272196

p_int:  0.918484527

p_ni:  0.081505979

p_wrong:  0.000009494

Data Source:  BioPlex

ARF1

Tchem

Family:  Enzyme

Novelty:  0.00208554

Score:  0.999

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (9)

Reactome (4)

KEGG (2)

PathwayCommons (3)

Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Intra-Golgi and retrograde Golgi-to-ER traffic	187 targets	R-HSA-6811442
Reactome	Intra-Golgi traffic	45 targets	R-HSA-6811438
Reactome	Membrane Trafficking	612 targets	R-HSA-199991
Reactome	Vesicle-mediated transport	725 targets	R-HSA-5653656

Name	Explore in Pharos	Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic	187 targets	R-HSA-6811442
Intra-Golgi traffic	45 targets	R-HSA-6811438
Membrane Trafficking	612 targets	R-HSA-199991
Vesicle-mediated transport	725 targets	R-HSA-5653656

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (14)

Functions (3)

Components (8)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
ARF guanyl-nucleotide exchange factor activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
inositol 1,4,5 trisphosphate binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
lipid binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (1)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	2	1	2		31.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	2		31.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell junction
Cell membrane
Cell projection
Coiled coil
Complete proteome
Cytoplasm
Guanine-nucleotide releasing factor
Lipid-binding

GWAS Trait Find Similar Targets

No Header	No Header
mathematical ability

MGI Phenotype Find Similar Targets

No Header	No Header
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cytohesin 2	VGNC:10978	746757
Macaque	cytohesin 2		718682
Mouse	cytohesin 2	MGI:1334255	19158
Rat	cytohesin 2	RGD:620398	116692
Dog	cytohesin 2	VGNC:50306	476423

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cytohesin 2
Macaque	cytohesin 2
Mouse	cytohesin 2
Rat	cytohesin 2
Dog	cytohesin 2

Publication Statistics

PubMed Score 22.12

PubMed score by year

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PubTator Score 143.01

PubTator score by year

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Related Publications

Text Mined References (59)

GeneRif Annotations (28)

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10

0 of 0

PMID	Year	Title