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Tbio
CYREN
Cell cycle regulator of non-homologous end joining

Protein Summary
Description
Isoform 1: Cell-cycle-specific inhibitor of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair during the S and G2 phases (PubMed:28959974). Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present (PubMed:28959974). Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination (PubMed:28959974). Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70, interaction restricted during the S and G2 phases only (PubMed:28959974). Molecular mechanisms governing classical NHEJ inhibition via interaction with XRCC5/Ku80 and XRCC6/Ku70 are unknown (PubMed:28959974). May act as a regulator of proteasome (By similarity). Isoform 4: Cell-cycle-specific inhibitor of classical non-ho ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393114
  • ENSP00000376823
  • ENSG00000122783
  • ENST00000424142
  • ENSP00000400024
  • ENST00000483029
  • ENSP00000473365
  • ENST00000617987
  • ENSP00000480430
  • ENST00000620897
  • ENSP00000481014

Symbol
  • C7orf49
  • MRI
  • MRI
  • MRI-2
  • C7orf49
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.06   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 45   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.06   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (21)
MRI1
Tbio
Family:  Enzyme
Novelty:  0.01167103
Score:  0.921
Data Source:  STRINGDB
GUCA2A
Tbio
Novelty:  0.00856211
Score:  0.718
Data Source:  STRINGDB
TRPV6
Tchem
Family:  IC
Novelty:  0.00383629
Score:  0.714
Data Source:  STRINGDB
AMHR2
Tbio
Family:  Kinase
Novelty:  0.00479939
Score:  0.712
Data Source:  STRINGDB
PRKG2
Tchem
Family:  Kinase
Novelty:  0.0138455
Score:  0.646
Data Source:  STRINGDB
CTNND2
Tbio
Novelty:  0.01178779
Score:  0.626
Data Source:  STRINGDB
METTL13
Tbio
Family:  Enzyme
Novelty:  0.15986409
Score:  0.616
Data Source:  STRINGDB
PHF5A
Tbio
Family:  Epigenetic
Novelty:  0.02989472
Score:  0.582
Data Source:  STRINGDB
P61580
Tdark
Novelty:  0.73924859
Score:  0.576
Data Source:  STRINGDB
COL10A1
Tbio
Novelty:  0.00521991
Score:  0.571
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
2
1
1
6.3
55.7
aspartate aminotransferase measurement
1
1
0
7.5
49.8
monocyte percentage of leukocytes
1
1
1
37.7
monocyte count
2
2
2
36.8
alkaline phosphatase measurement
1
1
1
21.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
1
6.3
55.7
aspartate aminotransferase measurement
0
7.5
49.8
monocyte percentage of leukocytes
1
37.7
monocyte count
2
36.8
alkaline phosphatase measurement
1
21.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cell cycle regulator of NHEJ
VGNC:4286
463748
Mouse
MGI:1925662
78412
Rat
RGD:1563238
500077
Horse
cell cycle regulator of NHEJ
VGNC:49237
100065055
Cow
cell cycle regulator of NHEJ
VGNC:52721
616626
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cell cycle regulator of NHEJ
Mouse
Rat
Horse
cell cycle regulator of NHEJ
Cow
cell cycle regulator of NHEJ
Publication Statistics
PubMed Score 121.06
PubMed score by year
PubTator Score 2392.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title