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Tchem
CYP4Z1
Cytochrome P450 4Z1

Protein Summary
Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334194
  • ENSP00000334246
  • ENSG00000186160

Symbol
  • CYP4A20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.6
cell line
0.54
tissue
0.5
chemical
0.46
metabolite
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.68   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.68   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (13)
POR
Tbio
Family:  Enzyme
Novelty:  0.00145147
Score:  0.631
Data Source:  STRINGDB
CYP4X1
Tbio
Novelty:  0.0592312
Score:  0.581
Data Source:  STRINGDB
CYP20A1
Tbio
Novelty:  0.11080329
Score:  0.581
Data Source:  STRINGDB
PPIG
Tchem
Family:  Enzyme
Novelty:  0.00014569
Score:  0.501
Data Source:  STRINGDB
RANBP3L
Tdark
Novelty:  0.35708446
Score:  0.486
Data Source:  STRINGDB
FA2H
Tbio
Family:  Enzyme
Novelty:  0.00449208
Score:  0.456
Data Source:  STRINGDB
TMOD3
Tbio
Novelty:  0.04744699
Score:  0.441
Data Source:  STRINGDB
CGNL1
Tbio
Novelty:  0.03970695
Score:  0.441
Data Source:  STRINGDB
SQLE
Tchem
Family:  Enzyme
Novelty:  0.0059338
Score:  0.438
Data Source:  STRINGDB
TUSC2
Tbio
Novelty:  0.05958876
Score:  0.438
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Metapathway biotransformation Phase I and II
WikiPathways
Metapathway biotransformation Phase I and II
WikiPathways
Vitamins A and D - action mechanisms
WikiPathways
Vitamins A and D - action mechanisms
WikiPathways
Vitamins A and D - action mechanisms
Name
Explore in Pharos
Explore in Source
Metapathway biotransformation Phase I and II
Metapathway biotransformation Phase I and II
Vitamins A and D - action mechanisms
Vitamins A and D - action mechanisms
Vitamins A and D - action mechanisms
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
71.4
mean platelet volume
1
1
1
67.8
body mass index
1
1
1
57.8
mean reticulocyte volume
1
1
1
48.3
mean corpuscular volume
1
1
1
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
71.4
mean platelet volume
1
67.8
body mass index
1
57.8
mean reticulocyte volume
1
48.3
mean corpuscular volume
1
46.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 25.68
PubMed score by year
PubTator Score 8.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title