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Tbio
CYP4X1
Cytochrome P450 4X1

Protein Summary
Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes and is located within a cluster of genes belonging to this superfamily on chromosome 1. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The expression pattern of a similar rat protein suggests that this protein may be involved in neurovascular function in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371901
  • ENSP00000360968
  • ENSG00000186377

Symbol
  • CYPIVX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.78
transcription factor perturbation
0.68
molecular function
0.6
PubMedID
0.59
tissue sample
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.98   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.98   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (11)
PPFIA1
Tbio
Novelty:  0.01904029
p_int:  0.999925943
p_ni:  0.000074057
Score:  0.394
Data Source:  BioPlex,STRINGDB
POR
Tbio
Family:  Enzyme
Novelty:  0.00145147
Score:  0.686
Data Source:  STRINGDB
CYP4Z1
Tchem
Novelty:  0.04967061
Score:  0.581
Data Source:  STRINGDB
PPIG
Tchem
Family:  Enzyme
Novelty:  0.00014569
Score:  0.52
Data Source:  STRINGDB
CGNL1
Tbio
Novelty:  0.03970695
Score:  0.461
Data Source:  STRINGDB
TMOD3
Tbio
Novelty:  0.04744699
Score:  0.441
Data Source:  STRINGDB
FA2H
Tbio
Family:  Enzyme
Novelty:  0.00449208
Score:  0.438
Data Source:  STRINGDB
SQLE
Tchem
Family:  Enzyme
Novelty:  0.0059338
Score:  0.438
Data Source:  STRINGDB
LSS
Tchem
Family:  Enzyme
Novelty:  0.00735187
Score:  0.428
Data Source:  STRINGDB
UGT2B10
Tbio
Family:  Enzyme
Novelty:  0.03135595
Score:  0.424
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
2
3
4
97.2
metabolite measurement
1
1
1
80.4
serum metabolite measurement
1
1
1
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
4
97.2
metabolite measurement
1
80.4
serum metabolite measurement
1
59
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 4 subfamily X member 1
VGNC:6120
456833
Mouse
MGI:1932403
81906
Rat
RGD:628719
246767
Dog
cytochrome P450 family 4 subfamily X member 1
VGNC:50372
482505
Horse
cytochrome P450 family 4 subfamily X member 1
VGNC:50393
100051552
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 4 subfamily X member 1
Mouse
Rat
Dog
cytochrome P450 family 4 subfamily X member 1
Horse
cytochrome P450 family 4 subfamily X member 1
Publication Statistics
PubMed Score 15.98
PubMed score by year
PubTator Score 5.72
PubTator score by year
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Related Publications
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PMID
Year
Title