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Tbio
CYP4F3
Docosahexaenoic acid omega-hydroxylase CYP4F3

Protein Summary
Description
Isoform CYP4F3A: Catalyzes the omega-hydroxylation of leukotriene-B(4), a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid. Isoform CYP4F3B: Shows arachidonic acid omega-hydroxylase activity by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) (PubMed:11461919, PubMed:16820285). Has a 30-fold higher Km for leukotriene-B(4) compared with CYP4F3A (PubMed:11461919). Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:16820285). Acts as a polyunsaturated omega-3 fatty acids hydroxylase: mediates conversion of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:16820285). This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticul ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221307
  • ENSP00000221307
  • ENSG00000186529
  • ENST00000585846
  • ENSP00000468105
  • ENST00000586182
  • ENSP00000466395
  • ENST00000591058
  • ENSP00000466988

Symbol
  • LTB4H
  • CPF3
  • CYP4F
  • LTB4H
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.92
gene perturbation
0.7
molecular function
0.67
tissue sample
0.65
transcription factor
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.06   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.06   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
CYP2J2
Tchem
Novelty:  0.00534181
Score:  0.941
Data Source:  STRINGDB
CYP2C9
Tchem
Novelty:  0.00041914
Score:  0.94
Data Source:  STRINGDB
ALOX5
Tclin
Family:  Enzyme
Novelty:  0.00062988
Score:  0.939
Data Source:  STRINGDB
CYP2B6
Tchem
Novelty:  0.00018351
Score:  0.938
Data Source:  STRINGDB
CYP2C19
Tchem
Novelty:  0.000394
Score:  0.938
Data Source:  STRINGDB
CYP2E1
Tchem
Novelty:  0.00030504
Score:  0.935
Data Source:  STRINGDB
CYP2U1
Tbio
Novelty:  0.04352257
Score:  0.934
Data Source:  STRINGDB
CYP2C8
Tchem
Novelty:  0.00186373
Score:  0.933
Data Source:  STRINGDB
LTA4H
Tchem
Family:  Enzyme
Novelty:  0.00505614
Score:  0.933
Data Source:  STRINGDB
PTGS2
Tclin
Family:  Enzyme
Novelty:  0.00007089
Score:  0.933
Data Source:  STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
1 – 3 of 3
PTGS2
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
ALOX5
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
PTGS1
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
Pathways (17)
Arachidonic acid metabolism (R-HSA-2142753)

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Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Eicosanoids
Reactome
Fatty acid metabolism
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biological oxidations
Cytochrome P450 - arranged by substrate type
Eicosanoids
Fatty acid metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
64.5
low density lipoprotein cholesterol measurement
2
2
2
40.1
total cholesterol measurement
1
1
1
22.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
64.5
low density lipoprotein cholesterol measurement
2
40.1
total cholesterol measurement
1
22.8
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 4 subfamily F member 3
VGNC:7475
748117
Mouse
MGI:1919304
72054
Cow
phylloquinone omega-hydroxylase CYP4F2
509506
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 4 subfamily F member 3
Mouse
Cow
phylloquinone omega-hydroxylase CYP4F2
Publication Statistics
PubMed Score 77.06
PubMed score by year
PubTator Score 5699.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title