Tbio CYP4F22 Cytochrome P450 4F22

Protein Summary

Description

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19 and encodes an enzyme thought to play a role in the 12(R)-lipoxygenase pathway. Mutations in this gene are the cause of ichthyosis lamellar type 3. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q6NT55
• Q8N8H4

Gene Name

• CYP4F22

Ensembl ID

• ENST00000269703
• ENSP00000269703
• ENSG00000171954
• ENST00000601005
• ENSP00000469866

Symbol

• LI3
• ARCI5
• INLNE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.71
cell type or tissue	0.65
gene perturbation	0.65
molecular function	0.53
tissue sample	0.49

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxygenase / Cytochrome P450 4f22

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxygenase / Cytochrome P450 4f22

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.94   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 71   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.94   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0