CYP4F22
Cytochrome P450 4F22
Protein Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19 and encodes an enzyme thought to play a role in the 12(R)-lipoxygenase pathway. Mutations in this gene are the cause of ichthyosis lamellar type 3. [provided by RefSeq, Jul 2008]
- ENST00000269703
- ENSP00000269703
- ENSG00000171954
- ENST00000601005
- ENSP00000469866
- LI3
- ARCI5
- INLNE
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
pathway | 0.71 | ||
cell type or tissue | 0.65 | ||
gene perturbation | 0.65 | ||
molecular function | 0.53 | ||
tissue sample | 0.49 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 51.01 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 71 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 51.01 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 71 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (24)
Nearest Tclin Targets
Pathways (18)
Reactome (15)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Arachidonic acid metabolism | ||||
Reactome | Biological oxidations | ||||
Reactome | Cytochrome P450 - arranged by substrate type | ||||
Reactome | Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) | ||||
Reactome | Disease | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Arachidonic acid metabolism | ||||
Biological oxidations | ||||
Cytochrome P450 - arranged by substrate type | ||||
Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) | ||||
Disease | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (4)
Components (2)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
lymphocyte count | 1 | 4 | 4 | 80.5 | |||||
reticulocyte measurement | 1 | 1 | 1 | 44.2 | |||||
monocyte percentage of leukocytes | 1 | 1 | 1 | 10.7 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
lymphocyte count | 4 | 80.5 | |||||
reticulocyte measurement | 1 | 44.2 | |||||
monocyte percentage of leukocytes | 1 | 10.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cytochrome P450 family 4 subfamily F member 22 | VGNC:7474 | 455798 | |||||
Macaque | cytochrome P450, family 4, subfamily F, polypeptide 22 | 718303 | ||||||
Mouse | MGI:2445210 | 320997 | ||||||
Rat | RGD:1308796 | 299566 | ||||||
Dog | cytochrome P450 family 4 subfamily F member 22 | VGNC:50366 | 484868 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cytochrome P450 family 4 subfamily F member 22 | |||||
Macaque | cytochrome P450, family 4, subfamily F, polypeptide 22 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cytochrome P450 family 4 subfamily F member 22 | |||||
Publication Statistics
PubMed Score 51.01
PubMed score by year
PubTator Score 50.17
PubTator score by year
Related Publications
Text Mined References (12)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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