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Tbio
CYP4B1
Cytochrome P450 4B1

Protein Summary
Description
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271153
  • ENSP00000271153
  • ENSG00000142973
  • ENST00000371923
  • ENSP00000360991

Symbol
  • CYPIVB1
  • P-450HP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
pathway
0.78
molecular function
0.7
kinase perturbation
0.66
small molecule perturbation
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.94   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.94   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
PKLR
Tbio
Family:  Kinase
Novelty:  0.00268398
p_int:  0.998874876
p_ni:  0.001125123
p_wrong:  1e-9
Score:  0.699
Data Source:  BioPlex,STRINGDB
PPIG
Tchem
Family:  Enzyme
Novelty:  0.00014569
Score:  0.597
Data Source:  STRINGDB
POR
Tbio
Family:  Enzyme
Novelty:  0.00145147
Score:  0.595
Data Source:  STRINGDB
CYP20A1
Tbio
Novelty:  0.11080329
Score:  0.499
Data Source:  STRINGDB
TRARG1
Tbio
Novelty:  0.07729433
Score:  0.478
Data Source:  STRINGDB
FMO1
Tbio
Family:  Enzyme
Novelty:  0.02090294
Score:  0.476
Data Source:  STRINGDB
VNN2
Tbio
Novelty:  0.02286648
Score:  0.476
Data Source:  STRINGDB
FMO3
Tbio
Family:  Enzyme
Novelty:  0.00567911
Score:  0.475
Data Source:  STRINGDB
SLC37A1
Tbio
Family:  Transporter
Novelty:  0.11329328
Score:  0.472
Data Source:  STRINGDB
CYP2F1
Tbio
Novelty:  0.02148932
Score:  0.465
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Eicosanoids
Reactome
Fatty acid metabolism
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biological oxidations
Cytochrome P450 - arranged by substrate type
Eicosanoids
Fatty acid metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
2
2
3
94.7
serum metabolite measurement
1
1
1
53.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
94.7
serum metabolite measurement
1
53.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 4 subfamily B member 1
VGNC:6119
456557
Macaque
cytochrome P450 4B1
709290
Mouse
MGI:103225
13120
Rat
RGD:2480
24307
Dog
cytochrome P450 family 4 subfamily B member 1
VGNC:50363
608452
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 4 subfamily B member 1
Macaque
cytochrome P450 4B1
Mouse
Rat
Dog
cytochrome P450 family 4 subfamily B member 1
Publication Statistics
PubMed Score 85.94
PubMed score by year
PubTator Score 32.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title