Tclin CYP3A5 Cytochrome P450 3A5

Protein Summary

Description

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Uniprot Accession IDs

• P20815
• A4D289
• B7Z5I7
• Q53WY8
• Q75MV0
• Q9HB56

Gene Name

• CYP3A5

Ensembl ID

• ENST00000222982
• ENSP00000222982
• ENSG00000106258
• ENST00000439761
• ENSP00000401269
• ENST00000646887
• ENSP00000496704

Symbol

• CP35
• PCN3
• CYPIIIA5
• P450PCN3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug	1
biological term	0.97
chemical	0.97
transcription factor perturbation	0.84
cell type or tissue	0.76

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxygenase / Cytochrome P450 3a5

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxygenase / Cytochrome P450 3a5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1214.36   (req: < 5)

Gene RIFs: 453   (req: <= 3)

Antibodies: 190   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1214.36   (req: >= 5)

Gene RIFs: 453   (req: > 3)

Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5