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Tclin
CYP3A4
Cytochrome P450 3A4

Protein Summary
Description
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide (PubMed:11159812). Catalyzes 4-beta-hydroxylation of cholesterol. May catalyze 25-hydroxylation of cholesterol in vitro (PubMed:21576599). This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This en ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336411
  • ENSP00000337915
  • ENSG00000160868

Symbol
  • CYP3A3
  • HLP
  • CP33
  • CP34
  • CYP3A
  • NF-25
  • CYP3A3
  • P450C3
  • CYPIIIA3
  • CYPIIIA4
  • P450PCN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
drug
1
molecular function
0.96
disease
0.85
pathway
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8043.8   (req: < 5)
Gene RIFs: 672   (req: <= 3)
Antibodies: 551   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8043.8   (req: >= 5)
Gene RIFs: 672   (req: > 3)
Antibodies: 551   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1814
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 40