You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
CYP3A4
Cytochrome P450 3A4

Protein Summary
Description
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide (PubMed:11159812). Catalyzes 4-beta-hydroxylation of cholesterol. May catalyze 25-hydroxylation of cholesterol in vitro (PubMed:21576599). This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This en ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336411
  • ENSP00000337915
  • ENSG00000160868

Symbol
  • CYP3A3
  • HLP
  • CP33
  • CP34
  • CYP3A
  • NF-25
  • CYP3A3
  • P450C3
  • CYPIIIA3
  • CYPIIIA4
  • P450PCN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
drug
1
molecular function
0.96
disease
0.85
pathway
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6971.84   (req: < 5)
Gene RIFs: 564   (req: <= 3)
Antibodies: 551   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6971.84   (req: >= 5)
Gene RIFs: 564   (req: > 3)
Antibodies: 551   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1771
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 39
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (39)
chlorpromazine
Rendered image for chlorpromazine
nilotinib
Rendered image for nilotinib
verapamil
Rendered image for verapamil
cisapride
Rendered image for cisapride
ergotamine
Rendered image for ergotamine
ketoconazole
Rendered image for ketoconazole
clotrimazole
Rendered image for clotrimazole
tamoxifen
Rendered image for tamoxifen
mibefradil
Rendered image for mibefradil
econazole
Rendered image for econazole
Protein-Protein Interactions (223)
CYP3A7
Tclin
Family:  Enzyme
Novelty:  0.00736888
p_int:  0.999999995
p_wrong:  5e-9
Score:  0.957
Data Source:  BioPlex,STRINGDB
UGT1A8
Tbio
Family:  Enzyme
Novelty:  0.00135129
Score:  0.975
Data Source:  STRINGDB
CYP2C9
Tchem
Novelty:  0.00041914
Score:  0.97
Data Source:  STRINGDB
UGT2B7
Tchem
Family:  Enzyme
Novelty:  0.00338073
Score:  0.969
Data Source:  STRINGDB
FMO3
Tbio
Family:  Enzyme
Novelty:  0.00567911
Score:  0.967
Data Source:  STRINGDB
FMO1
Tbio
Family:  Enzyme
Novelty:  0.02090294
Score:  0.963
Data Source:  STRINGDB
NR1I2
Tchem
Family:  NR
Novelty:  0.00058969
Score:  0.962
Data Source:  STRINGDB
UGT1A1
Tchem
Family:  Enzyme
Novelty:  0.00135044
Score:  0.961
Data Source:  STRINGDB
EPHX1
Tchem
Family:  Enzyme
Novelty:  0.00220169
Score:  0.96
Data Source:  STRINGDB
CES1
Tchem
Family:  Enzyme
Novelty:  0.00092608
Score:  0.958
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (46)
Aflatoxin activation and detoxification (R-HSA-5423646)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aflatoxin activation and detoxification
Reactome
Biological oxidations
Reactome
Biosynthesis of DHA-derived SPMs
Reactome
Biosynthesis of maresin-like SPMs
Reactome
Biosynthesis of maresins
Name
Explore in Pharos
Explore in Source
Aflatoxin activation and detoxification
Biological oxidations
Biosynthesis of DHA-derived SPMs
Biosynthesis of maresin-like SPMs
Biosynthesis of maresins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (35)
Find Similar Targets
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tacrolimus measurement
2
2
4
95
serum metabolite measurement
1
2
2
77.7
urinary metabolite measurement
1
2
2
75.1
viral load
1
1
1
70
ticagrelor measurement
1
2
2
65.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tacrolimus measurement
4
95
serum metabolite measurement
2
77.7
urinary metabolite measurement
2
75.1
viral load
1
70
ticagrelor measurement
2
65.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 3 subfamily A member 4
VGNC:13644
463582
Macaque
cytochrome P450, family 3, subfamily A, polypeptide 7
100144394
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 3 subfamily A member 4
Macaque
cytochrome P450, family 3, subfamily A, polypeptide 7
Publication Statistics
PubMed Score 6971.84
PubMed score by year
PubTator Score 5713.08
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title