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Tbio
CYP2S1
Cytochrome P450 2S1

Protein Summary
Description
Has a potential importance for extrahepatic xenobiotic metabolism. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310054
  • ENSP00000308032
  • ENSG00000167600

Symbol
  • CYPIIS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
PubMedID
0.72
histone modification site profile
0.65
tissue sample
0.59
chemical
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.97   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.97   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (97)
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.999999945
p_ni:  5.5e-8
Data Source:  BioPlex
FMN1
Tbio
Novelty:  0.00130542
p_int:  0.999994376
p_ni:  0.000005624
Score:  0.202
Data Source:  BioPlex,STRINGDB
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.999196897
p_ni:  0.000803102
p_wrong:  1e-9
Data Source:  BioPlex
CADM4
Tbio
Novelty:  0.05034541
p_int:  0.998999752
p_ni:  0.000984167
p_wrong:  0.000016081
Data Source:  BioPlex
TPRA1
Tdark
Family:  GPCR
Novelty:  0.16743826
p_int:  0.998745246
p_ni:  0.001254747
p_wrong:  7e-9
Data Source:  BioPlex
PRKCA
Tchem
Family:  Kinase
Novelty:  0.00057611
p_int:  0.998020611
p_ni:  0.001979389
Data Source:  BioPlex
LAMP2
Tbio
Novelty:  0.00168009
p_int:  0.997785409
p_ni:  0.002214591
Data Source:  BioPlex
PCDHA12
Tdark
Novelty:  0.71618264
p_int:  0.997177019
p_ni:  0.002707554
p_wrong:  0.000115427
Data Source:  BioPlex
PAG1
Tbio
Novelty:  0.01390911
p_int:  0.996551685
p_ni:  0.003447529
p_wrong:  7.86e-7
Data Source:  BioPlex
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
p_int:  0.996054572
p_ni:  0.003403103
p_wrong:  0.000542325
Score:  0.161
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
1 – 3 of 3
Pathways (15)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
CYP2E1 reactions
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Metabolism
Reactome
Miscellaneous substrates
Name
Explore in Pharos
Explore in Source
Biological oxidations
CYP2E1 reactions
Cytochrome P450 - arranged by substrate type
Metabolism
Miscellaneous substrates
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
4
8
93.3
mean corpuscular hemoglobin concentration
1
1
1
68.8
serum gamma-glutamyl transferase measurement
1
1
1
55.2
liver fibrosis measurement
2
1
2
52
apolipoprotein A 1 measurement
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
8
93.3
mean corpuscular hemoglobin concentration
1
68.8
serum gamma-glutamyl transferase measurement
1
55.2
liver fibrosis measurement
2
52
apolipoprotein A 1 measurement
1
47.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 2 subfamily S member 1
VGNC:10976
739649
Mouse
MGI:1921384
74134
Rat
RGD:1306078
308445
Dog
cytochrome P450 family 2 subfamily S member 1
VGNC:50356
484491
Horse
cytochrome P450 family 2 subfamily S member 1
VGNC:50430
100147675
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 2 subfamily S member 1
Mouse
Rat
Dog
cytochrome P450 family 2 subfamily S member 1
Horse
cytochrome P450 family 2 subfamily S member 1
Publication Statistics
PubMed Score 35.97
PubMed score by year
PubTator Score 27.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title