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Tchem
CYP2J2
Cytochrome P450 2J2

Protein Summary
Description
This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371204
  • ENSP00000360247
  • ENSG00000134716

Symbol
  • CPJ2
  • CYPIIJ2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
molecular function
0.81
histone modification site profile
0.78
biological term
0.7
virus perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 223.26   (req: < 5)
Gene RIFs: 89   (req: <= 3)
Antibodies: 308   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 223.26   (req: >= 5)
Gene RIFs: 89   (req: > 3)
Antibodies: 308   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (95)
MINDY2
Tbio
Novelty:  0.46783751
p_int:  0.999999771
p_ni:  1.24e-7
p_wrong:  1.05e-7
Score:  0.252
Data Source:  BioPlex,STRINGDB
TIPIN
Tbio
Novelty:  0.03919376
p_int:  0.999996851
p_ni:  0.000002839
p_wrong:  3.1e-7
Data Source:  BioPlex
ECPAS
Tbio
Novelty:  0.04004664
p_int:  0.999996236
p_ni:  0.000003764
Data Source:  BioPlex
NELFB
Tbio
Novelty:  0.05821821
p_int:  0.999879617
p_ni:  0.000120383
Data Source:  BioPlex
PDE4DIP
Tbio
Novelty:  0.03414104
p_int:  0.999696229
p_ni:  0.000264254
p_wrong:  0.000039516
Data Source:  BioPlex
USP25
Tchem
Family:  Enzyme
Novelty:  0.03671706
p_int:  0.999382772
p_ni:  0.000617228
Data Source:  BioPlex
PKD2
Tchem
Family:  IC
Novelty:  0.00305329
p_int:  0.999189282
p_ni:  0.000810718
Data Source:  BioPlex
VPS28
Tbio
Novelty:  0.02927315
p_int:  0.999017469
p_ni:  0.000970666
p_wrong:  0.000011865
Data Source:  BioPlex
LRBA
Tbio
Novelty:  0.00093369
p_int:  0.998352227
p_ni:  0.001647773
Data Source:  BioPlex
NELFE
Tbio
Novelty:  0.02136256
p_int:  0.997102325
p_ni:  0.00289629
p_wrong:  0.000001385
Data Source:  BioPlex
Nearest Tclin Targets (8)
Explore Nearest Tclin Targets
Pathways (24)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Fatty acid metabolism
Reactome
Fatty acids
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biological oxidations
Cytochrome P450 - arranged by substrate type
Fatty acid metabolism
Fatty acids
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
1
4.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
4.4
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 2 subfamily J member 2
VGNC:6118
456896
Macaque
cytochrome P450 2J2
693631
Mouse
MGI:1921769
74519
Rat
RGD:620007
65210
Dog
cytochrome P450 family 2 subfamily J member 2
VGNC:50354
610195
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 2 subfamily J member 2
Macaque
cytochrome P450 2J2
Mouse
Rat
Dog
cytochrome P450 family 2 subfamily J member 2
Publication Statistics
PubMed Score 223.26
PubMed score by year
PubTator Score 138.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title