Protein Summary
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase. This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are ...more
- ENST00000324071
- ENSP00000324648
- ENSG00000197408
- ENST00000643956
- ENSP00000495579
- CPB6
- EFVM
- IIB1
- P450
- CYP2B
- CYP2B7
- CYP2B7P
- CYPIIB6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
drug | 1 | ||
biological term | 0.92 | ||
disease | 0.75 | ||
molecular function | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5532.73 (req: < 5)
Gene RIFs: 211 (req: <= 3)
Antibodies: 315 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5532.73 (req: >= 5)
Gene RIFs: 211 (req: > 3)
Antibodies: 315 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 14
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 6
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (6)
Active Ligands (14)
Protein-Protein Interactions (209)
ATP2B3
Family: Transporter
Novelty: 0.00901493
p_int: 0.999012815
p_ni: 0.000987185
Score: 0.807
Data Source: BioPlex,STRINGDB
ATP2B2
Family: Transporter
Novelty: 0.007782
p_int: 0.997183862
p_ni: 0.002816138
Score: 0.534
Data Source: BioPlex,STRINGDB
ATP2B4
Family: Transporter
Novelty: 0.00560356
p_int: 0.989228158
p_ni: 0.010771842
Score: 0.646
Data Source: BioPlex,STRINGDB
DHRS4
Family: Enzyme
Novelty: 0.02992279
p_int: 0.889049698
p_ni: 0.110603856
p_wrong: 0.000346445
Score: 0.223
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (9)
Upstream (3)
Downstream (6)
1 – 3 of 3
Pathways (85)
Reactome (7)
KEGG (5)
PathwayCommons (2)
WikiPathways (71)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Biological oxidations | ||||
Reactome | CYP2E1 reactions | ||||
Reactome | Cytochrome P450 - arranged by substrate type | ||||
Reactome | Fatty acids | ||||
Reactome | Metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Biological oxidations | ||||
CYP2E1 reactions | ||||
Cytochrome P450 - arranged by substrate type | ||||
Fatty acids | ||||
Metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (6)
Components (4)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
cigarettes per day measurement | 4 | 2 | 4 | 94.9 | |||||
DDT metabolite measurement | 2 | 3 | 3 | 92.9 | |||||
nicotine metabolite ratio | 1 | 4 | 4 | 91.8 | |||||
caffeine metabolite measurement | 1 | 4 | 0 | 5.8 | 54.3 | ||||
organochlorine pesticide measurement | 1 | 1 | 1 | 45.7 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
cigarettes per day measurement | 4 | 94.9 | |||||
DDT metabolite measurement | 3 | 92.9 | |||||
nicotine metabolite ratio | 4 | 91.8 | |||||
caffeine metabolite measurement | 0 | 5.8 | 54.3 | ||||
organochlorine pesticide measurement | 1 | 45.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | cytochrome P450, family 2, subfamily B, polypeptide 6 | 678687 | ||||||
Mouse | MGI:107303 | 13090 | ||||||
Rat | RGD:2466 | 24300 | ||||||
Dog | cytochrome P450 2B11 | 474177 | ||||||
Horse | cytochrome P450 2B11-like | 100068603 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | cytochrome P450, family 2, subfamily B, polypeptide 6 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cytochrome P450 2B11 | |||||
Horse | cytochrome P450 2B11-like | |||||
Publication Statistics
PubMed Score 5532.73
PubMed score by year
PubTator Score 1960.06
PubTator score by year
Related Publications
Text Mined References (310)
GeneRif Annotations (211)
Items per page:
0 of 0
PMID | Year | Title |
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