Protein Summary
Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints. Has also a significant activity in oxidation of tazarotenic acid and may therefore metabol ...more
- ENST00000001146
- ENSP00000001146
- ENSG00000003137
- ENST00000546307
- ENSP00000443304
- CYP26A2
- P450RAI2
- RHFCA
- CYP26A2
- P450RAI2
- P450RAI-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.97 | ||
biological process | 0.93 | ||
molecular function | 0.84 | ||
pathway | 0.83 | ||
PubMedID | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 108.99 (req: < 5)
Gene RIFs: 25 (req: <= 3)
Antibodies: 252 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 108.99 (req: >= 5)
Gene RIFs: 25 (req: > 3)
Antibodies: 252 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 29
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (5)
Protein-Protein Interactions (87)
ECSIT
Novelty: 0.04690184
p_int: 0.975701584
p_ni: 0.024298416
p_wrong: 1e-9
Data Source: BioPlex
CRELD1
Novelty: 0.04938248
p_int: 0.946470026
p_ni: 0.053529888
p_wrong: 8.6e-8
Data Source: BioPlex
NDUFAF1
Novelty: 0.05630549
p_int: 0.939325185
p_ni: 0.060673197
p_wrong: 0.000001618
Data Source: BioPlex
PCYOX1
Family: Enzyme
Novelty: 0.18505748
p_int: 0.928030248
p_ni: 0.071969752
Data Source: BioPlex
MGST2
Family: Enzyme
Novelty: 0.04976733
p_int: 0.864742985
p_ni: 0.000009198
p_wrong: 0.135247817
Data Source: BioPlex
Nearest Tclin Targets (6)
Upstream (3)
Downstream (3)
1 – 3 of 3
Pathways (54)
Reactome (13)
KEGG (2)
WikiPathways (39)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Biological oxidations | ||||
Reactome | Cytochrome P450 - arranged by substrate type | ||||
Reactome | Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) | ||||
Reactome | Disease | ||||
Reactome | Diseases of metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Biological oxidations | ||||
Cytochrome P450 - arranged by substrate type | ||||
Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) | ||||
Disease | ||||
Diseases of metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (32)
Functions (5)
Components (3)
Processes (24)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Non-traceable Author Statement (NAS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
body height | 1 | 2 | 2 | 72.8 | |||||
1 | 1 | 0 | 1.1 | 27.3 | |||||
heel bone mineral density | 2 | 1 | 2 | 13.7 | |||||
mitochondrial heteroplasmy measurement | 1 | 1 | 1 | 0 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
body height | 2 | 72.8 | |||||
0 | 1.1 | 27.3 | |||||
heel bone mineral density | 2 | 13.7 | |||||
mitochondrial heteroplasmy measurement | 1 | 0 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cytochrome P450 26B1 | 738157 | ||||||
Mouse | MGI:2176159 | 232174 | ||||||
Rat | RGD:631379 | 312495 | ||||||
Dog | cytochrome P450 family 26 subfamily B member 1 | VGNC:50344 | 483120 | |||||
Horse | cytochrome P450 family 26 subfamily B member 1 | VGNC:50561 | 100059609 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | cytochrome P450 26B1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cytochrome P450 family 26 subfamily B member 1 | |||||
Horse | cytochrome P450 family 26 subfamily B member 1 | |||||
Publication Statistics
PubMed Score 108.99
PubMed score by year
PubTator Score 40.03
PubTator score by year
Related Publications
Text Mined References (44)
GeneRif Annotations (25)
Items per page:
0 of 0
PMID | Year | Title |
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