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Tchem
CYP26B1
Cytochrome P450 26B1

Protein Summary
Description
Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints. Has also a significant activity in oxidation of tazarotenic acid and may therefore metabol ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000001146
  • ENSP00000001146
  • ENSG00000003137
  • ENST00000546307
  • ENSP00000443304

Symbol
  • CYP26A2
  • P450RAI2
  • RHFCA
  • CYP26A2
  • P450RAI2
  • P450RAI-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
biological process
0.93
molecular function
0.84
pathway
0.83
PubMedID
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.99   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 252   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.99   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (87)
ECSIT
Tbio
Novelty:  0.04690184
p_int:  0.975701584
p_ni:  0.024298416
p_wrong:  1e-9
Data Source:  BioPlex
SCARB2
Tbio
Novelty:  0.0044075
p_int:  0.97151014
p_ni:  0.028489859
p_wrong:  1e-9
Data Source:  BioPlex
CRELD1
Tbio
Novelty:  0.04938248
p_int:  0.946470026
p_ni:  0.053529888
p_wrong:  8.6e-8
Data Source:  BioPlex
NDUFAF1
Tclin
Novelty:  0.05630549
p_int:  0.939325185
p_ni:  0.060673197
p_wrong:  0.000001618
Data Source:  BioPlex
PCYOX1
Tbio
Family:  Enzyme
Novelty:  0.18505748
p_int:  0.928030248
p_ni:  0.071969752
Data Source:  BioPlex
MGST2
Tbio
Family:  Enzyme
Novelty:  0.04976733
p_int:  0.864742985
p_ni:  0.000009198
p_wrong:  0.135247817
Data Source:  BioPlex
ALDH1A2
Tchem
Family:  Enzyme
Novelty:  0.00461371
Score:  0.978
Data Source:  STRINGDB
ALDH1A1
Tchem
Family:  Enzyme
Novelty:  0.0012292
Score:  0.958
Data Source:  STRINGDB
CRABP1
Tbio
Novelty:  0.00284292
Score:  0.956
Data Source:  Reactome,STRINGDB
CYP2S1
Tbio
Novelty:  0.02967417
Score:  0.93
Data Source:  STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
1 – 3 of 3
CYP3A5
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
CYP3A7
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
CYP3A4
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (54)
Biological oxidations (R-HSA-211859)

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Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
Reactome
Disease
Reactome
Diseases of metabolism
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytochrome P450 - arranged by substrate type
Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
Disease
Diseases of metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
2
2
72.8
1
1
0
1.1
27.3
heel bone mineral density
2
1
2
13.7
mitochondrial heteroplasmy measurement
1
1
1
0
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
72.8
0
1.1
27.3
heel bone mineral density
2
13.7
mitochondrial heteroplasmy measurement
1
0
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 26B1
738157
Mouse
MGI:2176159
232174
Rat
RGD:631379
312495
Dog
cytochrome P450 family 26 subfamily B member 1
VGNC:50344
483120
Horse
cytochrome P450 family 26 subfamily B member 1
VGNC:50561
100059609
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 26B1
Mouse
Rat
Dog
cytochrome P450 family 26 subfamily B member 1
Horse
cytochrome P450 family 26 subfamily B member 1
Publication Statistics
PubMed Score 108.99
PubMed score by year
PubTator Score 40.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title