Protein Summary
Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA. Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of t ...more
- ENST00000224356
- ENSP00000224356
- ENSG00000095596
- ENST00000371531
- ENSP00000360586
- CYP26
- P450RAI1
- CP26
- CYP26
- P450RAI
- P450RAI1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.91 | ||
pathway | 0.91 | ||
PubMedID | 0.9 | ||
molecular function | 0.86 | ||
cell type or tissue | 0.82 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 385.89 (req: < 5)
Gene RIFs: 30 (req: <= 3)
Antibodies: 268 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 385.89 (req: >= 5)
Gene RIFs: 30 (req: > 3)
Antibodies: 268 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 118
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (118)
Protein-Protein Interactions (118)
Nearest Tclin Targets (10)
Upstream (3)
Downstream (7)
1 – 3 of 3
Pathways (34)
Reactome (9)
KEGG (2)
WikiPathways (23)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Biological oxidations | ||||
Reactome | Cytochrome P450 - arranged by substrate type | ||||
Reactome | Metabolism | ||||
Reactome | Phase I - Functionalization of compounds | ||||
Reactome | RA biosynthesis pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Biological oxidations | ||||
Cytochrome P450 - arranged by substrate type | ||||
Metabolism | ||||
Phase I - Functionalization of compounds | ||||
RA biosynthesis pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (6)
Components (2)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Non-traceable Author Statement (NAS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (34)
Items per page:
1 – 5 of 34
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
triglyceride measurement | 12 | 6 | 16 | 2.3 | 98 | ||||
low density lipoprotein cholesterol measurement | 5 | 4 | 6 | 95.8 | |||||
apolipoprotein B measurement | 2 | 4 | 4 | 93.2 | |||||
high density lipoprotein cholesterol measurement | 7 | 4 | 8 | 90.9 | |||||
serum gamma-glutamyl transferase measurement | 2 | 3 | 3 | 90.5 | |||||
Items per page:
1 – 5 of 34
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
triglyceride measurement | 16 | 2.3 | 98 | ||||
low density lipoprotein cholesterol measurement | 6 | 95.8 | |||||
apolipoprotein B measurement | 4 | 93.2 | |||||
high density lipoprotein cholesterol measurement | 8 | 90.9 | |||||
serum gamma-glutamyl transferase measurement | 3 | 90.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cytochrome P450 family 26 subfamily A member 1 | VGNC:13049 | 450614 | |||||
Macaque | cytochrome P450, family 26, subfamily A, polypeptide 1 | 699519 | ||||||
Mouse | MGI:1096359 | 13082 | ||||||
Rat | RGD:620161 | 154985 | ||||||
Dog | cytochrome P450 family 26 subfamily A member 1 | VGNC:50337 | 486804 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cytochrome P450 family 26 subfamily A member 1 | |||||
Macaque | cytochrome P450, family 26, subfamily A, polypeptide 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cytochrome P450 family 26 subfamily A member 1 | |||||
Publication Statistics
PubMed Score 385.89
PubMed score by year
PubTator Score 167.42
PubTator score by year
Related Publications
Text Mined References (52)
GeneRif Annotations (30)
Items per page:
0 of 0
PMID | Year | Title |
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