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Tbio
CYP20A1
Cytochrome P450 20A1

Protein Summary
Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein lacks one amino acid of the conserved heme binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356079
  • ENSP00000348380
  • ENSG00000119004

Symbol
  • CYP-M
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
transcription factor binding site profile
0.69
tissue sample
0.67
small molecule perturbation
0.6
cell line
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.55   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.55   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
PIEZO1
Tchem
Family:  IC
Novelty:  0.00374633
p_int:  0.999956523
p_ni:  0.000043477
Score:  0.622
Data Source:  BioPlex,STRINGDB
VSIG1
Tbio
Novelty:  0.15442611
p_int:  0.999715109
p_ni:  0.000284869
p_wrong:  2.3e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
BTNL3
Tdark
Novelty:  0.27343899
p_int:  0.997402112
p_ni:  0.00253986
p_wrong:  0.000058029
Score:  0.309
Data Source:  BioPlex,STRINGDB
ICA1L
Tdark
Novelty:  0.69333512
Score:  0.763
Data Source:  STRINGDB
C8orf44
Tdark
Novelty:  4.22913257
Score:  0.725
Data Source:  STRINGDB
DCAF10
Tdark
Novelty:  2.6713128
Score:  0.697
Data Source:  STRINGDB
C17orf75
Tbio
Novelty:  0.08706784
Score:  0.694
Data Source:  STRINGDB
CYP27C1
Tbio
Novelty:  0.12582976
Score:  0.679
Data Source:  STRINGDB
GK5
Tbio
Family:  Kinase
Novelty:  0.06110952
Score:  0.657
Data Source:  STRINGDB
SYNJ2BP
Tbio
Novelty:  0.02520087
Score:  0.656
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Metapathway biotransformation Phase I and II
WikiPathways
Metapathway biotransformation Phase I and II
WikiPathways
Metapathway biotransformation Phase I and II
WikiPathways
Metapathway biotransformation Phase I and II
WikiPathways
Tamoxifen metabolism
Name
Explore in Pharos
Explore in Source
Metapathway biotransformation Phase I and II
Metapathway biotransformation Phase I and II
Metapathway biotransformation Phase I and II
Metapathway biotransformation Phase I and II
Tamoxifen metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
butyrylcholinesterase measurement
1
1
1
88.6
alkaline phosphatase measurement
2
1
1
10.1
81.3
white matter hyperintensity measurement
3
1
3
69.3
total cholesterol measurement
1
1
1
54.5
appendicular lean mass
1
1
1
52.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
butyrylcholinesterase measurement
1
88.6
alkaline phosphatase measurement
1
10.1
81.3
white matter hyperintensity measurement
3
69.3
total cholesterol measurement
1
54.5
appendicular lean mass
1
52.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450, family 20, subfamily A, polypeptide 1
459890
Macaque
cytochrome P450 20A1
715257
Mouse
MGI:1925201
77951
Rat
RGD:735221
316435
Dog
cytochrome P450 family 20 subfamily A member 1
VGNC:50351
100686469
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450, family 20, subfamily A, polypeptide 1
Macaque
cytochrome P450 20A1
Mouse
Rat
Dog
cytochrome P450 family 20 subfamily A member 1
Publication Statistics
PubMed Score 10.55
PubMed score by year
PubTator Score 172.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title