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Tchem
CYP1A2
Cytochrome P450 1A2

Protein Summary
Description
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343932
  • ENSP00000342007
  • ENSG00000140505

Symbol
  • CP12
  • CYPIA2
  • P3-450
  • P450(PA)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
drug
1
biological term
0.98
disease
0.85
molecular function
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2897.21   (req: < 5)
Gene RIFs: 271   (req: <= 3)
Antibodies: 661   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2897.21   (req: >= 5)
Gene RIFs: 271   (req: > 3)
Antibodies: 661   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1882
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 30
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (30)
chlorpromazine
Rendered image for chlorpromazine
fluphenazine
Rendered image for fluphenazine
prochlorperazine
Rendered image for prochlorperazine
quercetin
Rendered image for quercetin
nifedipine
Rendered image for nifedipine
trifluoperazine
Rendered image for trifluoperazine
econazole
Rendered image for econazole
phenelzine
Rendered image for phenelzine
perphenazine
Rendered image for perphenazine
tacrine
Rendered image for tacrine
Protein-Protein Interactions (153)
ASAH1
Tchem
Family:  Enzyme
Novelty:  0.00374228
p_int:  0.999328011
p_ni:  0.000671989
Score:  0.198
Data Source:  BioPlex,STRINGDB
EPHA4
Tchem
Family:  Kinase
Novelty:  0.00321698
p_int:  0.970303629
p_ni:  0.029696371
Score:  0.201
Data Source:  BioPlex,STRINGDB
FECH
Tchem
Family:  Enzyme
Novelty:  0.00282289
p_int:  0.938561054
p_ni:  0.061438946
Score:  0.77
Data Source:  BioPlex,STRINGDB
PGRMC1
Tchem
Novelty:  0.00364386
p_int:  0.774224731
p_ni:  0.225775269
Score:  0.943
Data Source:  BioPlex,STRINGDB
NAT2
Tbio
Family:  Enzyme
Novelty:  0.00150849
Score:  0.972
Data Source:  STRINGDB
NR1I3
Tchem
Family:  NR
Novelty:  0.00221694
Score:  0.966
Data Source:  STRINGDB
EPHX1
Tchem
Family:  Enzyme
Novelty:  0.00220169
Score:  0.962
Data Source:  STRINGDB
PPIG
Tchem
Family:  Enzyme
Novelty:  0.00014569
Score:  0.952
Data Source:  STRINGDB
CYP3A4
Tclin
Family:  Enzyme
Novelty:  0.00015515
Score:  0.952
Data Source:  STRINGDB
CYP7A1
Tchem
Family:  Enzyme
Novelty:  0.00148194
Score:  0.949
Data Source:  STRINGDB
Nearest Tclin Targets (9)
Explore Nearest Tclin Targets
Pathways (46)
Aflatoxin activation and detoxification (R-HSA-5423646)

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Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aflatoxin activation and detoxification
Reactome
Arachidonic acid metabolism
Reactome
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
Reactome
Biological oxidations
Reactome
Biosynthesis of DHA-derived SPMs
Name
Explore in Pharos
Explore in Source
Aflatoxin activation and detoxification
Arachidonic acid metabolism
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
Biological oxidations
Biosynthesis of DHA-derived SPMs
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (42)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (47)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
5
3
5
89.6
coffee consumption measurement
4
2
4
89
coffee consumption
5
3
6
88.6
glomerular filtration rate
4
2
6
82.7
creatinine measurement
2
2
3
82.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
5
89.6
coffee consumption measurement
4
89
coffee consumption
6
88.6
glomerular filtration rate
6
82.7
creatinine measurement
3
82.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 1 subfamily A member 2
VGNC:13404
735881
Mouse
MGI:88589
13077
Rat
RGD:2459
24297
Dog
cytochrome P450 family 1 subfamily A member 2
VGNC:50333
494010
Horse
cytochrome P450 family 1 subfamily A member 2
VGNC:50558
100062244
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 1 subfamily A member 2
Mouse
Rat
Dog
cytochrome P450 family 1 subfamily A member 2
Horse
cytochrome P450 family 1 subfamily A member 2
Publication Statistics
PubMed Score 2897.21
PubMed score by year
PubTator Score 1776.35
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title