Protein Summary
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple ...more
- ENST00000379727
- ENSP00000369050
- ENSG00000140465
- ENST00000395048
- ENSP00000378488
- ENST00000562201
- ENSP00000455340
- ENST00000564596
- ENSP00000457668
- ENST00000567032
- ENSP00000456585
- ENST00000569630
- ENSP00000455051
- AHH
- AHRR
- CP11
- CYP1
- CYPIA1
- P1-450
- P450-C
- P450DX
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
drug | 1 | ||
gene perturbation | 0.97 | ||
biological process | 0.96 | ||
molecular function | 0.86 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4613.94 (req: < 5)
Gene RIFs: 662 (req: <= 3)
Antibodies: 491 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4613.94 (req: >= 5)
Gene RIFs: 662 (req: > 3)
Antibodies: 491 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 53
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 261
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4