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Tclin
CYP19A1
Aromatase

Protein Summary
Description
Catalyzes the formation of aromatic C18 estrogens from C19 androgens. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396402
  • ENSP00000379683
  • ENSG00000137869
  • ENST00000396404
  • ENSP00000379685
  • ENST00000405913
  • ENSP00000383930
  • ENST00000557858
  • ENSP00000452627
  • ENST00000559878
  • ENSP00000453149

Symbol
  • ARO1
  • CYAR
  • CYP19
  • ARO
  • ARO1
  • CPV1
  • CYAR
  • CYP19
  • CYPXIX
  • P-450AROM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
drug
1
hub protein
0.95
disease
0.87
phenotype
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3663.71   (req: < 5)
Gene RIFs: 554   (req: <= 3)
Antibodies: 603   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3663.71   (req: >= 5)
Gene RIFs: 554   (req: > 3)
Antibodies: 603   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1226
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 15