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Tbio
CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

Protein Summary
Description
Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:18636086, PubMed:26670046, PubMed:27458237, PubMed:26997266, PubMed:27591049, PubMed:29291351, PubMed:18313383). Plays an important role in the regulation of pathways leading to NF-kappa-B activation (PubMed:12917689, PubMed:12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokine ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311559
  • ENSP00000308928
  • ENSG00000083799
  • ENST00000398568
  • ENSP00000381574
  • ENST00000427738
  • ENSP00000392025
  • ENST00000564326
  • ENSP00000454515
  • ENST00000569418
  • ENSP00000457576

Symbol
  • CYLD1
  • KIAA0849
  • EAC
  • MFT
  • SBS
  • TEM
  • BRSS
  • CDMT
  • MFT1
  • CYLD1
  • CYLDI
  • USPL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
biological process
0.99
hub protein
0.99
transcription factor perturbation
0.94
virus perturbation
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 662.94   (req: < 5)
Gene RIFs: 155   (req: <= 3)
Antibodies: 267   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 662.94   (req: >= 5)
Gene RIFs: 155   (req: > 3)
Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0