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Tbio
CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

Protein Summary
Description
Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:18636086, PubMed:26670046, PubMed:27458237, PubMed:26997266, PubMed:27591049, PubMed:29291351, PubMed:18313383). Plays an important role in the regulation of pathways leading to NF-kappa-B activation (PubMed:12917689, PubMed:12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokine ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311559
  • ENSP00000308928
  • ENSG00000083799
  • ENST00000398568
  • ENSP00000381574
  • ENST00000427738
  • ENSP00000392025
  • ENST00000564326
  • ENSP00000454515
  • ENST00000569418
  • ENSP00000457576

Symbol
  • CYLD1
  • KIAA0849
  • EAC
  • MFT
  • SBS
  • TEM
  • BRSS
  • CDMT
  • MFT1
  • CYLD1
  • CYLDI
  • USPL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
biological process
0.99
hub protein
0.99
transcription factor perturbation
0.94
virus perturbation
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 548.67   (req: < 5)
Gene RIFs: 155   (req: <= 3)
Antibodies: 267   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 548.67   (req: >= 5)
Gene RIFs: 155   (req: > 3)
Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (191)
GRB2
Tchem
Novelty:  0.00091605
p_int:  0.999999908
p_ni:  5.1e-8
p_wrong:  4e-8
Score:  0.2
Data Source:  BioPlex,STRINGDB
FGL2
Tbio
Novelty:  0.01108434
p_int:  0.999997813
p_ni:  0.000001319
p_wrong:  8.68e-7
Score:  0.252
Data Source:  BioPlex,STRINGDB
SPHK1
Tchem
Family:  Kinase
Novelty:  0.00147889
p_int:  0.999995995
p_ni:  0.000003984
p_wrong:  2.2e-8
Score:  0.716
Data Source:  BioPlex,STRINGDB
MID1IP1
Tbio
Novelty:  0.11443752
p_int:  0.99994539
p_ni:  0.00000341
p_wrong:  0.000051199
Data Source:  BioPlex
IKBKG
Tbio
Family:  Kinase
Novelty:  0.0006149
Score:  0.996
Data Source:  Reactome,STRINGDB
RNF31
Tbio
Family:  Enzyme
Novelty:  0.01394304
Score:  0.991
Data Source:  STRINGDB
TRAF6
Tbio
Novelty:  0.00109366
Score:  0.99
Data Source:  Reactome,STRINGDB
RIPK1
Tchem
Family:  Kinase
Novelty:  0.00230565
Score:  0.989
Data Source:  Reactome,STRINGDB
DDX58
Tbio
Family:  Enzyme
Novelty:  0.00080099
Score:  0.98
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.978
Data Source:  STRINGDB
Pathways (227)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (R-HSA-168928)

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Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Death Receptor Signalling
Reactome
Deubiquitination
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Death Receptor Signalling
Deubiquitination
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (46)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
11
5
2
2.2
99.1
3
3
0
1.5
94.4
2
3
0
1.8
90.7
Oral ulcer
1
2
0
1.1
84.6
1
1
1
79.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2.2
99.1
0
1.5
94.4
0
1.8
90.7
Oral ulcer
0
1.1
84.6
1
79.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CYLD lysine 63 deubiquitinase
VGNC:13691
465165
Macaque
CYLD lysine 63 deubiquitinase
695652
Mouse
MGI:1921506
74256
Rat
RGD:1308346
312937
Dog
CYLD lysine 63 deubiquitinase
VGNC:50293
611649
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CYLD lysine 63 deubiquitinase
Macaque
CYLD lysine 63 deubiquitinase
Mouse
Rat
Dog
CYLD lysine 63 deubiquitinase
Publication Statistics
PubMed Score 548.67
PubMed score by year
PubTator Score 321.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title