Tdark CYHR1 Cysteine and histidine-rich protein 1

Protein Summary

Uniprot Accession IDs

• Q6ZMK1
• B3KSX0
• D3DWM3
• Q9BSF6
• Q9BSU6

Gene Name

• CYHR1

Ensembl ID

• ENST00000306145
• ENSP00000304826
• ENSG00000187954
• ENST00000403000
• ENSP00000385962
• ENST00000424149
• ENSP00000414647
• ENST00000438911
• ENSP00000387426

Symbol

• KIAA0496
• CHRP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.97
kinase perturbation	0.88
transcription factor perturbation	0.88
small molecule perturbation	0.73
transcription factor binding site profile	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.21   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 23   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.21   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (40)

Explore Interacting Targets

1 – 10 of 40

• See Interactions on String-DB

UBE2K

Tbio

Novelty:  0.00214955

p_int:  0.999999991

p_ni:  7e-9

p_wrong:  2e-9

Score:  0.494

Data Source:  BioPlex,STRINGDB

FAM189B

Tbio

Novelty:  0.21064304

p_int:  0.999996392

p_ni:  0.000002859

p_wrong:  7.49e-7

Data Source:  BioPlex

DNAJB2

Tbio

Novelty:  0.046216

p_int:  0.999980154

p_ni:  0.000019846

Score:  0.2

Data Source:  BioPlex,STRINGDB

LITAF

Tbio

Family:  TF

Novelty:  0.0097203

p_int:  0.999846054

p_ni:  0.000125469

p_wrong:  0.000028477

Data Source:  BioPlex

LRRC73

Tdark

Novelty:  48

p_int:  0.999791709

p_ni:  0.000206256

p_wrong:  0.000002035

Data Source:  BioPlex

SDC1

Tbio

Novelty:  0.00044792

p_int:  0.999722829

p_ni:  0.000275122

p_wrong:  0.000002049

Data Source:  BioPlex

EPN3

Tbio

Novelty:  0.12685855

p_int:  0.999187636

p_ni:  0.000669742

p_wrong:  0.000142622

Score:  0.2

Data Source:  BioPlex,STRINGDB

HAO2

Tchem

Family:  Enzyme

Novelty:  0.03029536

p_int:  0.98972499

p_ni:  0.003604128

p_wrong:  0.006670883

Data Source:  BioPlex

RABGEF1

Tbio

Novelty:  0.02830695

p_int:  0.987022426

p_ni:  0.000346858

p_wrong:  0.012630716

Score:  0.363

Data Source:  BioPlex,STRINGDB

SLC45A2

Tbio

Family:  Transporter

Novelty:  0.00268252

p_int:  0.939471046

p_ni:  0.060049585

p_wrong:  0.000479369

Score:  0.19

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (3)

Functions (1)

Components (2)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (17)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 17

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alkaline phosphatase measurement	EFO_0004533	2	2	1	8	94.2
mathematical ability	EFO_0004875	4	4	4		93.4
sex hormone-binding globulin measurement	EFO_0004696	6	2	6		90.7
self reported educational attainment	EFO_0004784	5	3	4	5.9	90.6
red blood cell distribution width	EFO_0005192	2	2	2		83

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 17

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alkaline phosphatase measurement	EFO_0004533	1	8	94.2
mathematical ability	EFO_0004875	4		93.4
sex hormone-binding globulin measurement	EFO_0004696	6		90.7
self reported educational attainment	EFO_0004784	4	5.9	90.6
red blood cell distribution width	EFO_0005192	2		83

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Cytoplasm
Metal-binding
Reference proteome
Zinc
Zinc-finger

GWAS Trait Find Similar Targets

No Header	No Header
age at first birth measurement
alkaline phosphatase measurement
biological sex
blood metabolite measurement
cognitive function measurement
household income
intelligence
mathematical ability
mean corpuscular hemoglobin concentration
mean reticulocyte volume

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cysteine and histidine rich 1	VGNC:11963	464465
Macaque	cysteine and histidine rich 1		702522
Mouse	cysteine and histidine rich 1	MGI:1859320	54151
Rat	cysteine and histidine rich 1	RGD:2318728	100362155
Dog	cysteine and histidine rich 1	VGNC:50290	609854

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cysteine and histidine rich 1
Macaque	cysteine and histidine rich 1
Mouse	cysteine and histidine rich 1
Rat	cysteine and histidine rich 1
Dog	cysteine and histidine rich 1

Publication Statistics

PubMed Score 24.21

PubMed score by year

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PubTator Score 6.26

PubTator score by year

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Related Publications

Text Mined References (8)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title