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Tbio
CYGB
Cytoglobin

Protein Summary
Description
May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer. This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and may be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region as a retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293230
  • ENSP00000293230
  • ENSG00000161544

Symbol
  • STAP
  • HGB
  • STAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.73
disease
0.7
cell line
0.69
PubMedID
0.66
biological term
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1936.17   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 275   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1936.17   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 275   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
ZNF747
Tdark
Novelty:  9
p_int:  0.993604919
p_ni:  0.006394998
p_wrong:  8.3e-8
Score:  0.359
Data Source:  BioPlex,STRINGDB
NGB
Tbio
Novelty:  0.00247805
Score:  0.899
Data Source:  STRINGDB
GPT
Tbio
Family:  Enzyme
Novelty:  0.00003498
Score:  0.724
Data Source:  STRINGDB
EPO
Tbio
Novelty:  0.00013701
Score:  0.721
Data Source:  STRINGDB
GBE1
Tbio
Family:  Enzyme
Novelty:  0.00233237
Score:  0.712
Data Source:  STRINGDB
NAAA
Tchem
Family:  Enzyme
Novelty:  0.00368876
Score:  0.702
Data Source:  STRINGDB
ALB
Tchem
Novelty:  0.00000616
Score:  0.7
Data Source:  STRINGDB
RHBDF2
Tbio
Family:  Enzyme
Novelty:  0.02487334
Score:  0.697
Data Source:  STRINGDB
F2
Tclin
Family:  Enzyme
Novelty:  0.00004833
Score:  0.689
Data Source:  STRINGDB
CRP
Tbio
Novelty:  0.00001517
Score:  0.669
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Intracellular oxygen transport (R-HSA-8981607)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intracellular oxygen transport
Reactome
Metabolism
Reactome
Metabolism of nitric oxide: eNOS activation and regulation
Reactome
Transport of small molecules
Reactome
eNOS activation
Name
Explore in Pharos
Explore in Source
Intracellular oxygen transport
Metabolism
Metabolism of nitric oxide: eNOS activation and regulation
Transport of small molecules
eNOS activation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
4
3
5
89.3
reticulocyte measurement
3
5
5
88.3
mean corpuscular hemoglobin concentration
1
1
1
64.9
eosinophil count
2
1
2
44.2
mean reticulocyte volume
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
5
89.3
reticulocyte measurement
5
88.3
mean corpuscular hemoglobin concentration
1
64.9
eosinophil count
2
44.2
mean reticulocyte volume
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytoglobin
VGNC:9431
739843
Macaque
cytoglobin
707130
Mouse
MGI:2149481
114886
Rat
RGD:69415
170520
Dog
cytoglobin
VGNC:49090
609341
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytoglobin
Macaque
cytoglobin
Mouse
Rat
Dog
cytoglobin
Publication Statistics
PubMed Score 1936.17
PubMed score by year
PubTator Score 173.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title