You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CYFIP2
Cytoplasmic FMR1-interacting protein 2

Protein Summary
Description
Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000616178
  • ENSP00000479719
  • ENSG00000055163
  • ENST00000618329
  • ENSP00000484819
  • ENST00000620254
  • ENSP00000479968

Symbol
  • KIAA1168
  • PIR121
  • EIEE65
  • PIR121
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.92
interacting protein
0.91
transcription factor perturbation
0.88
trait
0.86
PubMedID
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.14   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.14   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (126)
NCKAP1
Tbio
Novelty:  0.03486454
p_int:  0.999998888
p_ni:  0.000001112
Score:  0.999
Data Source:  BioPlex,STRINGDB
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.999997625
p_ni:  0.000002375
Score:  0.998
Data Source:  BioPlex,STRINGDB
ABI2
Tbio
Novelty:  0.02324355
p_int:  0.999991404
p_ni:  0.000008596
Score:  0.996
Data Source:  BioPlex,STRINGDB
AMZ1
Tdark
Family:  Enzyme
Novelty:  0.246305
p_int:  0.999968565
p_ni:  0.000031435
Score:  0.392
Data Source:  BioPlex,STRINGDB
NCK2
Tbio
Novelty:  0.02220251
p_int:  0.99990282
p_ni:  0.00009718
Score:  0.569
Data Source:  BioPlex,STRINGDB
IKBIP
Tbio
Family:  Enzyme
Novelty:  0.18707639
p_int:  0.999737861
p_ni:  0.000262139
Data Source:  BioPlex
EPS8L1
Tbio
Family:  Enzyme
Novelty:  0.15959644
p_int:  0.999351018
p_ni:  0.000648982
Data Source:  BioPlex
NCK1
Tbio
Novelty:  0.00352084
p_int:  0.999332085
p_ni:  0.000667915
Score:  0.972
Data Source:  BioPlex,STRINGDB
ARHGAP12
Tbio
Family:  Enzyme
Novelty:  0.12113722
p_int:  0.998737419
p_ni:  0.001262581
Data Source:  BioPlex
NHSL2
Tdark
Novelty:  4.36275023
p_int:  0.998577212
p_ni:  0.001422788
Score:  0.799
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate WASPs and WAVEs
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Innate Immune System
RHO GTPase Effectors
RHO GTPases Activate WASPs and WAVEs
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
5
5
5
93.7
FEV/FEC ratio
1
1
1
83.2
T-cell immunoglobulin and mucin domain 1 measurement
1
3
3
82.4
serum alanine aminotransferase measurement
2
2
1
7.8
78.1
C-reactive protein measurement
4
4
4
78
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
5
93.7
FEV/FEC ratio
1
83.2
T-cell immunoglobulin and mucin domain 1 measurement
3
82.4
serum alanine aminotransferase measurement
1
7.8
78.1
C-reactive protein measurement
4
78
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cytoplasmic FMR1 interacting protein 2
714984
Mouse
MGI:1924134
76884
Dog
cytoplasmic FMR1 interacting protein 2
VGNC:49021
479317
Horse
cytoplasmic FMR1 interacting protein 2
VGNC:49120
100071224
Platypus
cytoplasmic FMR1 interacting protein 2
100075880
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cytoplasmic FMR1 interacting protein 2
Mouse
Dog
cytoplasmic FMR1 interacting protein 2
Horse
cytoplasmic FMR1 interacting protein 2
Platypus
cytoplasmic FMR1 interacting protein 2
Publication Statistics
PubMed Score 57.14
PubMed score by year
PubTator Score 17.48
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title