Protein Summary
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. Th ...more
- ENST00000305786
- ENSP00000307786
- ENSG00000172115
- ENST00000409409
- ENSP00000386270
- ENST00000409764
- ENSP00000387279
- CYC
- CYC
- HCS
- THC4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
transcription factor perturbation | 1 | ||
co-expressed gene | 0.95 | ||
histone modification site profile | 0.89 | ||
interacting protein | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21003.58 (req: < 5)
Gene RIFs: 65 (req: <= 3)
Antibodies: 1260 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21003.58 (req: >= 5)
Gene RIFs: 65 (req: > 3)
Antibodies: 1260 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0