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Tbio
CYBRD1
Cytochrome b reductase 1

Protein Summary
Description
Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells. This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed in the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological role in dietary iron absorption. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321348
  • ENSP00000319141
  • ENSG00000071967
  • ENST00000375252
  • ENSP00000364401
  • ENST00000409484
  • ENSP00000386739

Symbol
  • DCYTB
  • FRRS3
  • DCYTB
  • FRRS3
  • CYB561A2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
gene perturbation
0.92
microRNA
0.87
ligand (protein) perturbation
0.83
histone modification site profile
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.88   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.88   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
CDYL
Tchem
Family:  Epigenetic
Novelty:  0.03367841
p_int:  1
Score:  0.871
Data Source:  BioPlex,STRINGDB
MIER1
Tbio
Novelty:  0.00357772
p_int:  0.999998127
p_ni:  0.000001873
Score:  0.869
Data Source:  BioPlex,STRINGDB
MIER2
Tbio
Novelty:  0.85226416
p_int:  0.999996059
p_ni:  0.000003921
p_wrong:  2e-8
Score:  0.813
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.95046403
p_ni:  0.04953597
Score:  0.529
Data Source:  BioPlex,STRINGDB
HDAC2
Tclin
Family:  Epigenetic
Novelty:  0.0011024
p_int:  0.886891967
p_ni:  0.113108033
Score:  0.819
Data Source:  BioPlex,STRINGDB
FAM136A
Tdark
Novelty:  0.4050275
p_int:  0.846887067
p_ni:  0.153112933
p_wrong:  1e-9
Score:  0.311
Data Source:  BioPlex,STRINGDB
SLC11A2
Tchem
Family:  Transporter
Novelty:  0.00189409
Score:  0.892
Data Source:  STRINGDB
HEPH
Tbio
Novelty:  0.00609103
Score:  0.872
Data Source:  STRINGDB
SLC40A1
Tchem
Family:  Transporter
Novelty:  0.00222468
Score:  0.842
Data Source:  STRINGDB
HAMP
Tbio
Novelty:  0.00035828
Score:  0.796
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Iron uptake and transport (R-HSA-917937)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Iron uptake and transport
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Iron uptake and transport
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
4
7
97.1
BMI-adjusted hip circumference
1
11
11
90.3
BMI-adjusted waist-hip ratio
2
4
4
75.1
waist-hip ratio
1
3
3
63.9
pulse pressure measurement
1
1
1
57.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
7
97.1
BMI-adjusted hip circumference
11
90.3
BMI-adjusted waist-hip ratio
4
75.1
waist-hip ratio
3
63.9
pulse pressure measurement
1
57.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome b reductase 1
VGNC:157
737081
Mouse
MGI:2654575
73649
Rat
RGD:1305740
295669
Dog
cytochrome b reductase 1
VGNC:50286
478796
Horse
cytochrome b reductase 1
VGNC:51449
100063657
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome b reductase 1
Mouse
Rat
Dog
cytochrome b reductase 1
Horse
cytochrome b reductase 1
Publication Statistics
PubMed Score 87.88
PubMed score by year
PubTator Score 38.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title