You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CYBA
Cytochrome b-245 light chain

Protein Summary
Description
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261623
  • ENSP00000261623
  • ENSG00000051523

Symbol
  • p22-PHOX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
biological process
0.94
disease perturbation
0.83
histone modification site profile
0.79
chemical
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 522.68   (req: < 5)
Gene RIFs: 226   (req: <= 3)
Antibodies: 241   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 522.68   (req: >= 5)
Gene RIFs: 226   (req: > 3)
Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (191)
SLC2A12
Tbio
Family:  Transporter
Novelty:  0.01455533
p_int:  0.887487122
p_ni:  0.112512878
Score:  0.257
Data Source:  BioPlex,STRINGDB
NCF1
Tbio
Novelty:  0.00120288
Score:  0.997
Data Source:  Reactome,STRINGDB
NCF2
Tbio
Novelty:  0.00274685
Score:  0.997
Data Source:  Reactome,STRINGDB
CYBB
Tchem
Family:  IC
Novelty:  0.00054866
Score:  0.997
Data Source:  Reactome,STRINGDB
NOX1
Tchem
Family:  Enzyme
Novelty:  0.0016839
Score:  0.996
Data Source:  Reactome,STRINGDB
NOX4
Tchem
Family:  Enzyme
Novelty:  0.0009803
Score:  0.994
Data Source:  Reactome,STRINGDB
NCF4
Tbio
Novelty:  0.00560244
Score:  0.994
Data Source:  Reactome,STRINGDB
NOXO1
Tbio
Family:  Enzyme
Novelty:  0.02648748
Score:  0.99
Data Source:  Reactome,STRINGDB
NOX3
Tbio
Family:  Enzyme
Novelty:  0.01350666
Score:  0.989
Data Source:  Reactome,STRINGDB
NOXA1
Tbio
Family:  Enzyme
Novelty:  0.03052419
Score:  0.979
Data Source:  Reactome,STRINGDB
Pathways (34)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Cellular responses to external stimuli
Cellular responses to stress
Class I MHC mediated antigen processing & presentation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (60)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
3
5
5
98.2
reticulocyte count
5
6
12
96.4
hemoglobin measurement
2
5
5
94.3
reticulocyte measurement
3
4
7
93.6
mean corpuscular hemoglobin concentration
1
2
2
89.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
5
98.2
reticulocyte count
12
96.4
hemoglobin measurement
5
94.3
reticulocyte measurement
7
93.6
mean corpuscular hemoglobin concentration
2
89.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome b-245 alpha chain
VGNC:9028
468068
Macaque
cytochrome b-245 light chain
696748
Mouse
MGI:1316658
13057
Rat
RGD:620573
79129
Dog
cytochrome b-245 alpha chain
VGNC:50284
489664
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome b-245 alpha chain
Macaque
cytochrome b-245 light chain
Mouse
Rat
Dog
cytochrome b-245 alpha chain
Publication Statistics
PubMed Score 522.68
PubMed score by year
PubTator Score 279.66
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title