Tbio CYB5R3 NADH-cytochrome b5 reductase 3

Protein Summary

Description

Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. Alternate splicing results in multiple transcript variants. Mutations in this gene cause methemoglobinemias. [provided by RefSeq, Jan 2010]

Uniprot Accession IDs

• P00387
• B1AHF2
• B7Z7L3
• O75675
• Q8TDL8
• Q8WTS8
• Q9UEN4
• Q9UEN5
• Q9UL55
• Q9UL56
• B5R

Gene Name

• CYB5R3

Ensembl ID

• ENST00000352397
• ENSP00000338461
• ENSG00000100243
• ENST00000361740
• ENSP00000354468
• ENST00000402438
• ENSP00000385679
• ENST00000407332
• ENSP00000384457
• ENST00000407623
• ENSP00000384834

Symbol

• DIA1
• B5R
• DIA1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.94
transcription factor perturbation	0.88
protein domain	0.85
cellular component	0.81
disease perturbation	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.66   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 375   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.66   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 375   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0