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Tbio
CYB5R3
NADH-cytochrome b5 reductase 3

Protein Summary
Description
Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. Alternate splicing results in multiple transcript variants. Mutations in this gene cause methemoglobinemias. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000352397
  • ENSP00000338461
  • ENSG00000100243
  • ENST00000361740
  • ENSP00000354468
  • ENST00000402438
  • ENSP00000385679
  • ENST00000407332
  • ENSP00000384457
  • ENST00000407623
  • ENSP00000384834

Symbol
  • DIA1
  • B5R
  • DIA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
transcription factor perturbation
0.88
protein domain
0.85
cellular component
0.81
disease perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.01   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 375   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.01   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 375   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (135)
RTN4
Tbio
Novelty:  0.00080371
p_int:  0.999641484
p_ni:  0.000358516
Score:  0.283
Data Source:  BioPlex,STRINGDB
CPVL
Tbio
Family:  Enzyme
Novelty:  0.0616903
p_int:  0.997399763
p_ni:  0.002590112
p_wrong:  0.000010125
Score:  0.156
Data Source:  BioPlex,STRINGDB
RTN1
Tbio
Novelty:  0.01828064
p_int:  0.995051704
p_ni:  0.004948288
p_wrong:  8e-9
Score:  0.291
Data Source:  BioPlex,STRINGDB
TMEM159
Tdark
Novelty:  0.22237677
p_int:  0.990975061
p_ni:  0.009024938
p_wrong:  2e-9
Data Source:  BioPlex
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.981981884
p_ni:  0.018018116
Data Source:  BioPlex
TSPAN11
Tdark
Novelty:  0.37247094
p_int:  0.977395435
p_ni:  0.022604564
p_wrong:  1e-9
Score:  0.186
Data Source:  BioPlex,STRINGDB
USP47
Tchem
Family:  Enzyme
Novelty:  0.07579226
p_int:  0.956586132
p_ni:  0.043413868
Data Source:  BioPlex
ACTL6A
Tbio
Novelty:  0.01892162
p_int:  0.906905389
p_ni:  0.093094559
p_wrong:  5.3e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
SLC37A3
Tdark
Family:  Transporter
Novelty:  0.21571546
p_int:  0.88898317
p_ni:  0.110883953
p_wrong:  0.000132878
Score:  0.174
Data Source:  BioPlex,STRINGDB
GML
Tdark
Novelty:  0.04982168
p_int:  0.878674117
p_ni:  0.120230206
p_wrong:  0.001095677
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Biological oxidations
Immune System
Innate Immune System
Metabolism
Metabolism of vitamins and cofactors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
4
4
94.8
hematocrit
3
3
3
94.2
hemoglobin measurement
3
2
3
92.6
mean platelet volume
2
3
3
91.1
metabolite measurement
1
2
2
87.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
94.8
hematocrit
3
94.2
hemoglobin measurement
3
92.6
mean platelet volume
3
91.1
metabolite measurement
2
87.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome b5 reductase 3
VGNC:6693
458883
Macaque
cytochrome b5 reductase 3
714058
Mouse
MGI:94893
109754
Rat
RGD:2502
25035
Dog
cytochrome b5 reductase 3
VGNC:50283
474479
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome b5 reductase 3
Macaque
cytochrome b5 reductase 3
Mouse
Rat
Dog
cytochrome b5 reductase 3
Publication Statistics
PubMed Score 144.01
PubMed score by year
PubTator Score 100.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title