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Tbio
CYB5R2
NADH-cytochrome b5 reductase 2

Protein Summary
Description
NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1). The protein encoded by this gene belongs to the flavoprotein pyridine nucleotide cytochrome reductase family of proteins. Cytochrome b-type NAD(P)H oxidoreductases are implicated in many processes including cholesterol biosynthesis, fatty acid desaturation and elongation, and respiratory burst in neutrophils and macrophages. Cytochrome b5 reductases have soluble and membrane-bound forms that are the product of alternative splicing. In animal cells, the membrane-bound form binds to the endoplasmic reticulum, where it is a member of a fatty acid desaturation complex. Alternative splicing results in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299498
  • ENSP00000299498
  • ENSG00000166394
  • ENST00000524790
  • ENSP00000435916
  • ENST00000533558
  • ENSP00000437041

Symbol
  • B5R.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
gene perturbation
0.71
histone modification site profile
0.68
PubMedID
0.58
cell type or tissue
0.45


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.37   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.37   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
HBB
Tbio
Novelty:  0.00049683
Score:  0.905
Data Source:  Reactome,STRINGDB
CYB5A
Tbio
Novelty:  0.00047376
Score:  0.829
Data Source:  STRINGDB
POR
Tbio
Family:  Enzyme
Novelty:  0.00145147
Score:  0.738
Data Source:  STRINGDB
FANK1
Tbio
Novelty:  0.12389783
Score:  0.71
Data Source:  STRINGDB
OVCH2
Tdark
Family:  Enzyme
Novelty:  0.32719563
Score:  0.618
Data Source:  STRINGDB
FDXR
Tbio
Family:  Enzyme
Novelty:  0.00171588
Score:  0.569
Data Source:  STRINGDB
CYB5B
Tbio
Novelty:  0.09395308
Score:  0.54
Data Source:  STRINGDB
DECR1
Tbio
Family:  Enzyme
Novelty:  0.02699187
Score:  0.532
Data Source:  STRINGDB
SC5D
Tbio
Family:  Enzyme
Novelty:  0.02446366
Score:  0.51
Data Source:  STRINGDB
DPYD
Tclin
Family:  Enzyme
Novelty:  0.00207216
Score:  0.49
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Erythrocytes take up carbon dioxide and release oxygen (R-HSA-1237044)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Erythrocytes take up carbon dioxide and release oxygen
Reactome
O2/CO2 exchange in erythrocytes
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Erythrocytes take up carbon dioxide and release oxygen
O2/CO2 exchange in erythrocytes
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
39.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
39.7
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome b5 reductase 2
VGNC:3136
451005
Macaque
NADH-cytochrome b5 reductase 2
710527
Mouse
MGI:2444415
320635
Rat
RGD:1308421
365345
Dog
cytochrome b5 reductase 2
VGNC:50282
485367
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome b5 reductase 2
Macaque
NADH-cytochrome b5 reductase 2
Mouse
Rat
Dog
cytochrome b5 reductase 2
Publication Statistics
PubMed Score 11.37
PubMed score by year
PubTator Score 2.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title