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Tbio
CYB5R1
NADH-cytochrome b5 reductase 1

Protein Summary
Description
NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367249
  • ENSP00000356218
  • ENSG00000159348

Symbol
  • NQO3A2
  • B5R1
  • B5R2
  • B5R.1
  • NQO3A2
  • humb5R2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
kinase perturbation
0.93
histone modification site profile
0.91
transcription factor perturbation
0.88
protein domain
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.31   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 224   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.31   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
KCNA5
Tclin
Family:  IC
Novelty:  0.00182891
p_int:  0.998374552
p_ni:  0.001625448
Data Source:  BioPlex
CACNG1
Tbio
Family:  IC
Novelty:  0.11899252
p_int:  0.997649266
p_ni:  0.002350734
p_wrong:  1e-9
Data Source:  BioPlex
SLC7A14
Tbio
Family:  Transporter
Novelty:  0.1613451
p_int:  0.996048006
p_ni:  0.003951725
p_wrong:  2.69e-7
Data Source:  BioPlex
MFSD8
Tbio
Novelty:  0.03388459
p_int:  0.995678851
p_ni:  0.004321149
Data Source:  BioPlex
HEPACAM2
Tbio
Novelty:  0.19192547
p_int:  0.994873332
p_ni:  0.005126668
Data Source:  BioPlex
IL20RA
Tbio
Novelty:  0.02416816
p_int:  0.994259009
p_ni:  0.005740991
Data Source:  BioPlex
PCDHGA5
Tdark
Novelty:  2.13631603
p_int:  0.993552136
p_ni:  0.006447864
Data Source:  BioPlex
PCDHGB2
Tdark
Novelty:  1.16587709
p_int:  0.97719202
p_ni:  0.022807947
p_wrong:  3.3e-8
Data Source:  BioPlex
MCOLN3
Tchem
Family:  IC
Novelty:  0.03209262
p_int:  0.958279187
p_ni:  0.041720813
Data Source:  BioPlex
NAAA
Tchem
Family:  Enzyme
Novelty:  0.00368876
p_int:  0.955148842
p_ni:  0.044851158
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Erythrocytes take up carbon dioxide and release oxygen (R-HSA-1237044)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Erythrocytes take up carbon dioxide and release oxygen
Reactome
Hemostasis
Reactome
O2/CO2 exchange in erythrocytes
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Name
Explore in Pharos
Explore in Source
Erythrocytes take up carbon dioxide and release oxygen
Hemostasis
O2/CO2 exchange in erythrocytes
Platelet activation, signaling and aggregation
Platelet degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
0
1.1
92.2
mean platelet volume
3
1
3
75.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
92.2
mean platelet volume
3
75.7
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome b5 reductase 1
VGNC:1226
740001
Macaque
cytochrome b5 reductase 1
704519
Mouse
MGI:1919267
72017
Rat
RGD:1306084
304805
Dog
cytochrome b5 reductase 1
VGNC:50281
606823
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome b5 reductase 1
Macaque
cytochrome b5 reductase 1
Mouse
Rat
Dog
cytochrome b5 reductase 1
Publication Statistics
PubMed Score 13.31
PubMed score by year
PubTator Score 1.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title