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Tbio
CYB5D2
Neuferricin

Protein Summary
Description
Heme-binding protein which promotes neuronal but not astrocyte differentiation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301391
  • ENSP00000301391
  • ENSG00000167740
  • ENST00000575251
  • ENSP00000458903
  • ENST00000577075
  • ENSP00000458352
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.77
virus perturbation
0.76
transcription factor binding site profile
0.72
tissue
0.64
tissue sample
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.16   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.16   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
NPTX2
Tbio
Novelty:  0.00686292
p_int:  0.999999992
p_ni:  7e-9
Score:  0.214
Data Source:  BioPlex,STRINGDB
AGTRAP
Tbio
Novelty:  0.02295361
p_int:  0.999999841
p_ni:  6.5e-8
p_wrong:  9.4e-8
Score:  0.214
Data Source:  BioPlex,STRINGDB
PTX3
Tbio
Novelty:  0.00153752
p_int:  0.999999547
p_ni:  4.53e-7
Score:  0.188
Data Source:  BioPlex,STRINGDB
ABLIM1
Tbio
Novelty:  0.05511373
p_int:  0.999999488
p_ni:  5.12e-7
Score:  0.158
Data Source:  BioPlex,STRINGDB
NPTXR
Tbio
Novelty:  0.00727951
p_int:  0.999995395
p_ni:  0.000004598
p_wrong:  6e-9
Score:  0.228
Data Source:  BioPlex,STRINGDB
GRIPAP1
Tbio
Novelty:  0.09814766
p_int:  0.998756814
p_ni:  0.001243186
Score:  0.19
Data Source:  BioPlex,STRINGDB
SLC30A5
Tbio
Family:  Transporter
Novelty:  0.02432633
p_int:  0.998342858
p_ni:  0.001657136
p_wrong:  6e-9
Data Source:  BioPlex
TNFSF8
Tbio
Novelty:  0.01292216
p_int:  0.969065755
p_ni:  0.030934245
Data Source:  BioPlex
POLDIP3
Tbio
Family:  Enzyme
Novelty:  0.03072373
p_int:  0.966584135
p_ni:  0.033415864
p_wrong:  1e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
KLHL42
Tdark
Novelty:  0.25822395
p_int:  0.962247715
p_ni:  0.037725468
p_wrong:  0.000026818
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
10
7
4
1.1
95.5
waist-hip ratio
1
1
1
52
hematocrit
2
1
2
49.5
heel bone mineral density
2
2
2
49.2
visceral adipose tissue measurement
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
95.5
waist-hip ratio
1
52
hematocrit
2
49.5
heel bone mineral density
2
49.2
visceral adipose tissue measurement
1
47.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2684848
192986
Rat
RGD:1359124
303293
Dog
cytochrome b5 domain containing 2
VGNC:50280
489437
Horse
cytochrome b5 domain containing 2
VGNC:50462
100060725
Cow
cytochrome b5 domain containing 2
VGNC:50262
515356
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
cytochrome b5 domain containing 2
Horse
cytochrome b5 domain containing 2
Cow
cytochrome b5 domain containing 2
Publication Statistics
PubMed Score 6.16
PubMed score by year
PubTator Score 3.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title