Tbio CYB5D2 Neuferricin

Protein Summary

Description

Heme-binding protein which promotes neuronal but not astrocyte differentiation.

Uniprot Accession IDs

• Q8WUJ1
• B2R7R6
• D3DTJ9
• I3L1K2

Gene Name

• CYB5D2

Ensembl ID

• ENST00000301391
• ENSP00000301391
• ENSG00000167740
• ENST00000575251
• ENSP00000458903
• ENST00000577075
• ENSP00000458352

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.77
virus perturbation	0.76
transcription factor binding site profile	0.72
tissue	0.64
tissue sample	0.64

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Neuferricin

Protein / Receptor / Neuferricin

DTO Classes

Protein / Signaling / Neuferricin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.16   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 74   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.16   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (54)

Explore Interacting Targets

1 – 10 of 54

• See Interactions on String-DB

NPTX2

Tbio

Novelty:  0.00686292

p_int:  0.999999992

p_ni:  7e-9

Score:  0.214

Data Source:  BioPlex,STRINGDB

AGTRAP

Tbio

Novelty:  0.02295361

p_int:  0.999999841

p_ni:  6.5e-8

p_wrong:  9.4e-8

Score:  0.214

Data Source:  BioPlex,STRINGDB

PTX3

Tbio

Novelty:  0.00153752

p_int:  0.999999547

p_ni:  4.53e-7

Score:  0.188

Data Source:  BioPlex,STRINGDB

ABLIM1

Tbio

Novelty:  0.05511373

p_int:  0.999999488

p_ni:  5.12e-7

Score:  0.158

Data Source:  BioPlex,STRINGDB

NPTXR

Tbio

Novelty:  0.00727951

p_int:  0.999995395

p_ni:  0.000004598

p_wrong:  6e-9

Score:  0.228

Data Source:  BioPlex,STRINGDB

GRIPAP1

Tbio

Novelty:  0.09814766

p_int:  0.998756814

p_ni:  0.001243186

Score:  0.19

Data Source:  BioPlex,STRINGDB

SLC30A5

Tbio

Family:  Transporter

Novelty:  0.02432633

p_int:  0.998342858

p_ni:  0.001657136

p_wrong:  6e-9

Data Source:  BioPlex

TNFSF8

Tbio

Novelty:  0.01292216

p_int:  0.969065755

p_ni:  0.030934245

Data Source:  BioPlex

POLDIP3

Tbio

Family:  Enzyme

Novelty:  0.03072373

p_int:  0.966584135

p_ni:  0.033415864

p_wrong:  1e-9

Score:  0.188

Data Source:  BioPlex,STRINGDB

KLHL42

Tdark

Novelty:  0.25822395

p_int:  0.962247715

p_ni:  0.037725468

p_wrong:  0.000026818

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (3)

Functions (1)

Components (1)

Processes (1)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
heme binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
type II diabetes mellitus	EFO_0001360	10	7	4	1.1	95.5
waist-hip ratio	EFO_0004343	1	1	1		52
hematocrit	EFO_0004348	2	1	2		49.5
heel bone mineral density	EFO_0009270	2	2	2		49.2
visceral adipose tissue measurement	EFO_0004765	1	1	1		47.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
type II diabetes mellitus	EFO_0001360	4	1.1	95.5
waist-hip ratio	EFO_0004343	1		52
hematocrit	EFO_0004348	2		49.5
heel bone mineral density	EFO_0009270	2		49.2
visceral adipose tissue measurement	EFO_0004765	1		47.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Neurogenesis
Polymorphism
Reference proteome
Secreted
Signal

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist-hip ratio
heel bone mineral density
hematocrit
type II diabetes mellitus
visceral adipose tissue measurement
waist-hip ratio

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	cytochrome b5 domain containing 2	MGI:2684848	192986
Rat	cytochrome b5 domain containing 2	RGD:1359124	303293
Dog	cytochrome b5 domain containing 2	VGNC:50280	489437
Horse	cytochrome b5 domain containing 2	VGNC:50462	100060725
Cow	cytochrome b5 domain containing 2	VGNC:50262	515356

Species	Name	OMA	EggNOG	Inparanoid
Mouse	cytochrome b5 domain containing 2
Rat	cytochrome b5 domain containing 2
Dog	cytochrome b5 domain containing 2
Horse	cytochrome b5 domain containing 2
Cow	cytochrome b5 domain containing 2

Publication Statistics

PubMed Score 6.16

PubMed score by year

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PubTator Score 3.90

PubTator score by year

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Related Publications

Text Mined References (8)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title