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Tbio
CYB5B
Cytochrome b5 type B

Protein Summary
Description
Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000512062
  • ENSP00000423679
  • ENSG00000103018

Symbol
  • CYB5M
  • OMB5
  • OMB5
  • CYB5-M
  • CYPB5M
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
histone modification site profile
0.88
transcription factor binding site profile
0.88
transcription factor perturbation
0.88
kinase perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.46   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.46   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (137)
KIAA1586
Tdark
Novelty:  2.30999532
p_int:  0.999997868
p_ni:  0.000002132
Data Source:  BioPlex
GDE1
Tbio
Family:  Enzyme
Novelty:  0.05854843
p_int:  0.999978897
p_ni:  0.000003035
p_wrong:  0.000018068
Data Source:  BioPlex
NR3C1
Tclin
Family:  NR
Novelty:  0.00029396
p_int:  0.99996607
p_ni:  0.00003393
Data Source:  BioPlex
XPO7
Tbio
Novelty:  0.05412704
p_int:  0.999936739
p_ni:  0.000063261
Data Source:  BioPlex
DCUN1D5
Tchem
Novelty:  0.56719852
p_int:  0.999915515
p_ni:  0.000084477
p_wrong:  7e-9
Data Source:  BioPlex
THADA
Tbio
Novelty:  0.06983966
p_int:  0.999899664
p_ni:  0.000100336
Data Source:  BioPlex
MTOR
Tclin
Family:  Kinase
Novelty:  0.00012333
p_int:  0.999875524
p_ni:  0.000124476
Data Source:  BioPlex
USP24
Tbio
Family:  Enzyme
Novelty:  0.07281326
p_int:  0.999820346
p_ni:  0.000179654
Data Source:  BioPlex
KIAA0391
Tbio
Family:  Enzyme
Novelty:  0.02276396
p_int:  0.999548183
p_ni:  0.000451817
Data Source:  BioPlex
XPO6
Tbio
Novelty:  0.03229708
p_int:  0.999476655
p_ni:  0.000523345
Score:  0.203
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Metabolism
Reactome
Phase I - Functionalization of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Metabolism
Phase I - Functionalization of compounds
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (38)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
4
3
5
92.5
body mass index
6
3
6
89.4
body fat percentage
2
2
2
83.1
high density lipoprotein cholesterol measurement
3
1
3
81.3
triglyceride measurement
3
3
3
81.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
5
92.5
body mass index
6
89.4
body fat percentage
2
83.1
high density lipoprotein cholesterol measurement
3
81.3
triglyceride measurement
3
81.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome b5 type B
VGNC:9029
454202
Macaque
cytochrome b5 type B (outer mitochondrial membrane)
705093
Mouse
MGI:1913677
66427
Rat
RGD:621551
80773
Horse
cytochrome b5 type B
VGNC:50460
100067168
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome b5 type B
Macaque
cytochrome b5 type B (outer mitochondrial membrane)
Mouse
Rat
Horse
cytochrome b5 type B
Publication Statistics
PubMed Score 13.46
PubMed score by year
PubTator Score 7.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title