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Tbio
CYB5A
Cytochrome b5

Protein Summary
Description
Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. The protein encoded by this gene is a membrane-bound cytochrome that reduces ferric hemoglobin (methemoglobin) to ferrous hemoglobin, which is required for stearyl-CoA-desaturase activity. Defects in this gene are a cause of type IV hereditary methemoglobinemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340533
  • ENSP00000341625
  • ENSG00000166347
  • ENST00000397914
  • ENSP00000381011
  • ENST00000494131
  • ENSP00000436461

Symbol
  • CYB5
  • CYB5
  • MCB5
  • METAG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
transcription factor perturbation
0.91
cellular component
0.9
kinase perturbation
0.88
disease perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2017.75   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 338   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2017.75   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 338   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (107)
ENDOD1
Tdark
Family:  Enzyme
Novelty:  0.26430864
p_int:  0.995702313
p_ni:  0.003856802
p_wrong:  0.000440885
Score:  0.189
Data Source:  BioPlex,STRINGDB
HSPA14
Tbio
Novelty:  0.01714625
p_int:  0.991417582
p_ni:  0.008579967
p_wrong:  0.000002451
Score:  0.224
Data Source:  BioPlex,STRINGDB
B7ZAP0
Tbio
Family:  Enzyme
Novelty:  0.2377644
p_int:  0.977353759
p_ni:  0.022645789
p_wrong:  4.52e-7
Score:  0.166
Data Source:  BioPlex,STRINGDB
AGPAT4
Tbio
Family:  Enzyme
Novelty:  0.10376004
p_int:  0.952828701
p_ni:  0.047171297
p_wrong:  1e-9
Score:  0.289
Data Source:  BioPlex,STRINGDB
TAB1
Tchem
Family:  Kinase
Novelty:  0.00721424
p_int:  0.948614067
p_ni:  0.051385932
Score:  0.216
Data Source:  BioPlex,STRINGDB
BCAP31
Tbio
Novelty:  0.01363316
p_int:  0.851396712
p_ni:  0.148603288
Score:  0.554
Data Source:  BioPlex,STRINGDB
SNX2
Tbio
Novelty:  0.03880384
p_int:  0.775555575
p_ni:  0.224444425
Score:  0.172
Data Source:  BioPlex,STRINGDB
CYB5R3
Tbio
Family:  Enzyme
Novelty:  0.00774258
Score:  0.995
Data Source:  Reactome,STRINGDB
POR
Tbio
Family:  Enzyme
Novelty:  0.00145147
Score:  0.964
Data Source:  STRINGDB
CYCS
Tchem
Novelty:  0.00014004
Score:  0.947
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (56)
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane (R-HSA-9609523)

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Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Protein localization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
5
9
11
99
sex hormone-binding globulin measurement
4
3
4
87.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
11
99
sex hormone-binding globulin measurement
4
87.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome b5 type A
VGNC:9912
735913
Macaque
cytochrome b5 type A (microsomal)
694723
Mouse
MGI:1926952
109672
Rat
RGD:620558
64001
Dog
cytochrome b5 type A (microsomal)
476167
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome b5 type A
Macaque
cytochrome b5 type A (microsomal)
Mouse
Rat
Dog
cytochrome b5 type A (microsomal)
Publication Statistics
PubMed Score 2017.75
PubMed score by year
PubTator Score 727.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title