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Tbio
CYB561D2
Cytochrome b561 domain-containing protein 2

Protein Summary
Description
Two-heme-containing cytochrome that catalyzes ascorbate-dependent trans-membrane ferric-chelate reduction.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000232508
  • ENSP00000232508
  • ENSG00000114395
  • ENST00000418577
  • ENSP00000391209
  • ENST00000424512
  • ENSP00000410663
  • ENST00000425346
  • ENSP00000400454

Symbol
  • 101F6
  • 101F6
  • TSP10
  • XXcos-LUCA11.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.79
cell type or tissue
0.74
histone modification site profile
0.72
tissue sample
0.65
kinase perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (19)
NPRL2
Tbio
Family:  Enzyme
Novelty:  0.02848752
Score:  0.694
Data Source:  STRINGDB
HYAL2
Tbio
Family:  Enzyme
Novelty:  0.00740331
Score:  0.673
Data Source:  STRINGDB
CACNA2D2
Tclin
Family:  IC
Novelty:  0.02041017
Score:  0.653
Data Source:  STRINGDB
OVCH1
Tdark
Family:  Enzyme
Novelty:  0.26472251
Score:  0.644
Data Source:  STRINGDB
FRRS1
Tdark
Family:  Enzyme
Novelty:  0.04371703
Score:  0.581
Data Source:  STRINGDB
HYAL1
Tbio
Family:  Enzyme
Novelty:  0.00756819
Score:  0.563
Data Source:  STRINGDB
RASSF1
Tbio
Novelty:  0.00137149
Score:  0.548
Data Source:  STRINGDB
SPAM1
Tbio
Family:  Enzyme
Novelty:  0.0041597
Score:  0.514
Data Source:  STRINGDB
HYAL3
Tbio
Family:  Enzyme
Novelty:  0.14284007
Score:  0.473
Data Source:  STRINGDB
TWSG1
Tbio
Novelty:  0.00255544
Score:  0.447
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
5
11
99.2
reticulocyte count
2
4
8
98.7
mean reticulocyte volume
1
1
1
85.1
4
3
0
1.1
73
chronotype measurement
1
1
0
1
66.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
11
99.2
reticulocyte count
8
98.7
mean reticulocyte volume
1
85.1
0
1.1
73
chronotype measurement
0
1
66.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome b-561 domain containing 2
744998
Macaque
cytochrome b-561 domain containing 2
702280
Mouse
MGI:1929280
56368
Rat
RGD:1359644
363137
Dog
cytochrome b-561 domain containing 2
484759
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome b-561 domain containing 2
Macaque
cytochrome b-561 domain containing 2
Mouse
Rat
Dog
cytochrome b-561 domain containing 2
Publication Statistics
PubMed Score 9.00
PubMed score by year
PubTator Score 6.47
PubTator score by year
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Related Publications
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PMID
Year
Title