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Tbio
CXXC4
CXXC-type zinc finger protein 4

Protein Summary
Description
Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1. This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000426831
  • ENSP00000412267
  • ENSG00000168772

Symbol
  • IDAX
  • IDAX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.83
PubMedID
0.68
transcription factor perturbation
0.68
transcription factor binding site profile
0.67
gene perturbation
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.17   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.17   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (26)
DVL1
Tchem
Novelty:  0.00356876
Score:  0.982
Data Source:  STRINGDB
DVL3
Tbio
Novelty:  0.01606014
Score:  0.926
Data Source:  Reactome,STRINGDB
DVL2
Tbio
Novelty:  0.00833084
Score:  0.917
Data Source:  Reactome,STRINGDB
TET2
Tchem
Family:  Enzyme
Novelty:  0.00141899
Score:  0.823
Data Source:  STRINGDB
TOPORS
Tbio
Family:  Enzyme
Novelty:  0.03910082
Score:  0.652
Data Source:  STRINGDB
MTAP
Tchem
Family:  Enzyme
Novelty:  0.00485488
Score:  0.643
Data Source:  STRINGDB
AXIN1
Tbio
Novelty:  0.00175842
Score:  0.593
Data Source:  STRINGDB
PUS7
Tbio
Family:  Enzyme
Novelty:  0.04867669
Score:  0.534
Data Source:  STRINGDB
PDCD4
Tchem
Novelty:  0.00213303
Score:  0.529
Data Source:  STRINGDB
TCF7L2
Tbio
Family:  TF
Novelty:  0.00178694
Score:  0.526
Data Source:  STRINGDB
Pathways (8)
Negative regulation of TCF-dependent signaling by DVL-interacting proteins (R-HSA-5368598)

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
TCF dependent signaling in response to WNT
Name
Explore in Pharos
Explore in Source
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
Signal Transduction
Signaling by WNT
TCF dependent signaling in response to WNT
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
2
2
63.4
insomnia measurement
2
1
0
1
9.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
2
63.4
insomnia measurement
0
1
9.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 29.17
PubMed score by year
PubTator Score 8.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title