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Tbio
CXXC1
CXXC-type zinc finger protein 1

Protein Summary
Description
Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. This gene encodes a protein that functions as a transcriptional activator that binds specifically to non-methylated CpG motifs through its CXXC domain. The protein is a component of the SETD1 complex, regulates gene expression and is essential for vertebrate development. [provided by RefSeq, Sep 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285106
  • ENSP00000285106
  • ENSG00000154832
  • ENST00000412036
  • ENSP00000390475

Symbol
  • CFP1
  • CGBP
  • PCCX1
  • PHF18
  • CFP1
  • CGBP
  • SPP1
  • PCCX1
  • PHF18
  • hCGBP
  • ZCGPC1
  • HsT2645
  • 2410002I16Rik
  • 5830420C16Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
protein domain
0.92
transcription factor binding site profile
0.87
molecular function
0.86
biological process
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.58   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 240   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.58   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (107)
SETD1B
Tbio
Family:  Epigenetic
Novelty:  0.03331663
p_int:  0.999999973
p_ni:  2.6e-8
p_wrong:  1e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
SETD1A
Tbio
Family:  Epigenetic
Novelty:  0.00248544
p_int:  0.999999875
p_ni:  1.25e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
WDR5
Tchem
Novelty:  0.0059945
p_int:  0.999999811
p_ni:  1.89e-7
Score:  0.988
Data Source:  BioPlex,STRINGDB
BOD1
Tbio
Novelty:  0.06404805
p_int:  0.999999801
p_ni:  1.96e-7
p_wrong:  3e-9
Score:  0.392
Data Source:  BioPlex,STRINGDB
BOD1L1
Tdark
Novelty:  0.26485597
p_int:  0.999999418
p_ni:  5.82e-7
Score:  0.877
Data Source:  BioPlex,STRINGDB
HCFC2
Tbio
Novelty:  0.12260416
p_int:  0.999999346
p_ni:  6.54e-7
Score:  0.754
Data Source:  BioPlex,STRINGDB
EPB41L5
Tbio
Novelty:  0.0391959
p_int:  0.999990085
p_ni:  0.000009915
Score:  0.54
Data Source:  BioPlex,STRINGDB
MDK
Tchem
Novelty:  0.00145301
p_int:  0.999953135
p_ni:  0.000046865
Score:  0.513
Data Source:  BioPlex,STRINGDB
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.999949858
p_ni:  0.000050142
Data Source:  BioPlex
NUP50
Tbio
Novelty:  0.03424725
p_int:  0.999794293
p_ni:  0.000205707
Score:  0.199
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
IRE1alpha activates chaperones (R-HSA-381070)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
IRE1alpha activates chaperones
Reactome
Metabolism of proteins
Reactome
Unfolded Protein Response (UPR)
Reactome
XBP1(S) activates chaperone genes
Name
Explore in Pharos
Explore in Source
IRE1alpha activates chaperones
Metabolism of proteins
Unfolded Protein Response (UPR)
XBP1(S) activates chaperone genes
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
1
1
49.5
high density lipoprotein cholesterol measurement
2
1
2
21.5
phospholipid measurement
1
1
1
15.8
1
1
0
1.1
3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
49.5
high density lipoprotein cholesterol measurement
2
21.5
phospholipid measurement
1
15.8
0
1.1
3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CXXC finger protein 1
VGNC:7814
455419
Macaque
CXXC finger protein 1
700341
Mouse
MGI:1921572
74322
Rat
RGD:1310755
291440
Dog
CXXC finger protein 1
480217
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CXXC finger protein 1
Macaque
CXXC finger protein 1
Mouse
Rat
Dog
CXXC finger protein 1
Publication Statistics
PubMed Score 72.58
PubMed score by year
PubTator Score 23.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title