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Tchem
CXCR5
C-X-C chemokine receptor type 5

Protein Summary
Description
Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation. This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292174
  • ENSP00000292174
  • ENSG00000160683

Symbol
  • BLR1
  • MDR15
  • BLR1
  • CD185
  • MDR15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.66
PubMedID
0.63
transcription factor
0.62
microRNA
0.58
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 482.44   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 638   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 482.44   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 638   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 19
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (19)
CHEMBL3719134
Rendered image for CHEMBL3719134
CHEMBL3715759
Rendered image for CHEMBL3715759
CHEMBL3717162
Rendered image for CHEMBL3717162
CHEMBL3718924
Rendered image for CHEMBL3718924
CHEMBL3718468
Rendered image for CHEMBL3718468
CHEMBL3716436
Rendered image for CHEMBL3716436
CHEMBL3717871
Rendered image for CHEMBL3717871
CHEMBL3719066
Rendered image for CHEMBL3719066
Protein-Protein Interactions (410)
CXCL13
Tbio
Novelty:  0.00118688
Score:  0.995
Data Source:  Reactome,STRINGDB
CCL5
Tchem
Novelty:  0.00032607
Score:  0.982
Data Source:  STRINGDB
CCL19
Tbio
Novelty:  0.00169711
Score:  0.975
Data Source:  STRINGDB
CCL4
Tbio
Novelty:  0.00069278
Score:  0.969
Data Source:  STRINGDB
CCL21
Tbio
Novelty:  0.00130736
Score:  0.969
Data Source:  STRINGDB
CXCL12
Tchem
Novelty:  0.00026817
Score:  0.969
Data Source:  STRINGDB
GNAI2
Tchem
Novelty:  0.03014729
Score:  0.963
Data Source:  STRINGDB
CCL28
Tbio
Novelty:  0.00513161
Score:  0.959
Data Source:  STRINGDB
CCL20
Tbio
Novelty:  0.00158263
Score:  0.954
Data Source:  STRINGDB
CXCL10
Tbio
Novelty:  0.00040194
Score:  0.953
Data Source:  STRINGDB
Pathways (16)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
4
0
1.1
91.4
4
3
2
1.1
81.5
3
2
0
1.1
76.4
primary biliary cirrhosis
3
3
0
1.4
70.5
3
2
2
1.1
69.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
91.4
2
1.1
81.5
0
1.1
76.4
primary biliary cirrhosis
0
1.4
70.5
2
1.1
69.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-X-C motif chemokine receptor 5
VGNC:11334
451595
Macaque
C-X-C motif chemokine receptor 5
701792
Mouse
MGI:103567
12145
Rat
RGD:62010
29363
Dog
C-X-C motif chemokine receptor 5
VGNC:39752
489378
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-X-C motif chemokine receptor 5
Macaque
C-X-C motif chemokine receptor 5
Mouse
Rat
Dog
C-X-C motif chemokine receptor 5
Publication Statistics
PubMed Score 482.44
PubMed score by year
PubTator Score 198.26
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
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PMID
Year
Title