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Tbio
CXCL6
C-X-C motif chemokine 6

Protein Summary
Description
Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226317
  • ENSP00000226317
  • ENSG00000124875

Symbol
  • GCP2
  • SCYB6
  • GCP2
  • CKA-3
  • GCP-2
  • SCYB6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.77
disease
0.6
kinase perturbation
0.6
biological process
0.57
molecular function
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.61   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.61   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (262)
CXCR1
Tchem
Family:  GPCR
Novelty:  0.00224501
Score:  0.99
Data Source:  Reactome,STRINGDB
CXCL1
Tbio
Novelty:  0.00059123
Score:  0.988
Data Source:  STRINGDB
CXCR2
Tchem
Family:  GPCR
Novelty:  0.00108314
Score:  0.982
Data Source:  STRINGDB
CXCL11
Tbio
Novelty:  0.00077765
Score:  0.98
Data Source:  STRINGDB
CXCL2
Tbio
Novelty:  0.00201175
Score:  0.969
Data Source:  STRINGDB
CCL5
Tchem
Novelty:  0.00032607
Score:  0.965
Data Source:  STRINGDB
PPBP
Tbio
Novelty:  0.00048307
Score:  0.964
Data Source:  STRINGDB
CCL20
Tbio
Novelty:  0.00158263
Score:  0.963
Data Source:  STRINGDB
CXCL12
Tchem
Novelty:  0.00026817
Score:  0.959
Data Source:  STRINGDB
CXCL16
Tbio
Novelty:  0.00517074
Score:  0.954
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
Pathways (15)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
5
5
98.4
C-X-C motif chemokine 6 measurement
1
2
2
96.2
neutrophil percentage of leukocytes
2
3
3
95.8
lymphocyte percentage of leukocytes
2
3
3
94.9
blood protein measurement
1
2
2
88.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
5
98.4
C-X-C motif chemokine 6 measurement
2
96.2
neutrophil percentage of leukocytes
3
95.8
lymphocyte percentage of leukocytes
3
94.9
blood protein measurement
2
88.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-X-C motif chemokine ligand 6
VGNC:8665
740729
Pig
alveolar macrophage-derived chemotactic factor-II
396900
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-X-C motif chemokine ligand 6
Pig
alveolar macrophage-derived chemotactic factor-II
Publication Statistics
PubMed Score 97.61
PubMed score by year
PubTator Score 67.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title