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Tbio
CXCL5
C-X-C motif chemokine 5

Protein Summary
Description
Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes. This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296027
  • ENSP00000296027
  • ENSG00000163735

Symbol
  • ENA78
  • SCYB5
  • SCYB5
  • ENA-78
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.96
PubMedID
0.95
biological term
0.69
disease
0.69
tissue sample
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 357.44   (req: < 5)
Gene RIFs: 88   (req: <= 3)
Antibodies: 490   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 357.44   (req: >= 5)
Gene RIFs: 88   (req: > 3)
Antibodies: 490   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (325)
FBLN2
Tbio
Novelty:  0.01340024
p_int:  0.999931489
p_ni:  0.000068466
p_wrong:  4.5e-8
Data Source:  BioPlex
OLFM2
Tbio
Novelty:  0.06929963
p_int:  0.999390542
p_ni:  0.000602776
p_wrong:  0.000006682
Data Source:  BioPlex
VWDE
Tdark
Novelty:  0.37298162
p_int:  0.996550532
p_ni:  0.003371146
p_wrong:  0.000078322
Data Source:  BioPlex
CD109
Tbio
Novelty:  0.01280272
p_int:  0.912208409
p_ni:  0.087786724
p_wrong:  0.000004867
Data Source:  BioPlex
TMEM131
Tdark
Novelty:  0.02152783
p_int:  0.890310328
p_ni:  0.109689672
Data Source:  BioPlex
ERO1B
Tbio
Novelty:  0.06389159
p_int:  0.876602226
p_ni:  0.123263617
p_wrong:  0.000134157
Data Source:  BioPlex
CXCR2
Tchem
Family:  GPCR
Novelty:  0.00108314
Score:  0.993
Data Source:  STRINGDB
CXCR1
Tchem
Family:  GPCR
Novelty:  0.00224501
Score:  0.984
Data Source:  STRINGDB
CXCL3
Tbio
Novelty:  0.01001656
Score:  0.98
Data Source:  STRINGDB
CCL20
Tbio
Novelty:  0.00158263
Score:  0.98
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
Pathways (24)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
2
2
2
90.2
lymphocyte percentage of leukocytes
2
2
2
89.7
neutrophil count
3
2
3
89
myeloid white cell count
2
2
2
88.9
monocyte percentage of leukocytes
2
2
2
86.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
2
90.2
lymphocyte percentage of leukocytes
2
89.7
neutrophil count
3
89
myeloid white cell count
2
88.9
monocyte percentage of leukocytes
2
86.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-X-C motif chemokine ligand 5
VGNC:8663
740377
Mouse
MGI:1096868
20311
Dog
alveolar macrophage chemotactic factor-like
106557449
Horse
C-X-C motif chemokine ligand 6
100033988
Cow
chemokine (C-X-C motif) ligand 5
281735
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-X-C motif chemokine ligand 5
Mouse
Dog
alveolar macrophage chemotactic factor-like
Horse
C-X-C motif chemokine ligand 6
Cow
chemokine (C-X-C motif) ligand 5
Publication Statistics
PubMed Score 357.44
PubMed score by year
PubTator Score 204.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title