CXCL3
C-X-C motif chemokine 3
Protein Summary
Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]
- ENST00000296026
- ENSP00000296026
- ENSG00000163734
- GRO3
- GROG
- SCYB3
- GRO3
- GROg
- MIP2B
- SCYB3
- MIP-2b
- CINC-2b
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 1 | ||
virus perturbation | 0.99 | ||
histone modification site profile | 0.82 | ||
small molecule perturbation | 0.79 | ||
cell type or tissue | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 80.4 (req: < 5)
Gene RIFs: 23 (req: <= 3)
Antibodies: 257 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 80.4 (req: >= 5)
Gene RIFs: 23 (req: > 3)
Antibodies: 257 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (283)
Nearest Tclin Targets (3)
Downstream (3)
1 – 3 of 3
Pathways (108)
Reactome (8)
KEGG (13)
WikiPathways (87)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Chemokine receptors bind chemokines | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Chemokine receptors bind chemokines | ||||
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (1)
Components (2)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (23)
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
neutrophil count | 5 | 4 | 5 | 98.1 | |||||
myeloid white cell count | 3 | 3 | 3 | 96.1 | |||||
neutrophil percentage of leukocytes | 2 | 2 | 2 | 90.2 | |||||
lymphocyte percentage of leukocytes | 2 | 2 | 2 | 89.7 | |||||
leukocyte count | 4 | 2 | 4 | 89.3 | |||||
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
neutrophil count | 5 | 98.1 | |||||
myeloid white cell count | 3 | 96.1 | |||||
neutrophil percentage of leukocytes | 2 | 90.2 | |||||
lymphocyte percentage of leukocytes | 2 | 89.7 | |||||
leukocyte count | 4 | 89.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (4)
1 – 4 of 4
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | C-X-C motif chemokine ligand 3 | VGNC:8662 | 461255 | |||||
Mouse | MGI:108068 | 14825 | ||||||
Cow | chemokine (C-X-C motif) ligand 2 | 281214 | ||||||
Opossum | growth-regulated alpha protein | 100023783 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | C-X-C motif chemokine ligand 3 | |||||
Mouse | ||||||
Cow | chemokine (C-X-C motif) ligand 2 | |||||
Opossum | growth-regulated alpha protein | |||||
Publication Statistics
PubMed Score 80.40
PubMed score by year
PubTator Score 57.57
PubTator score by year
Related Publications
Text Mined References (45)
GeneRif Annotations (23)
Items per page:
0 of 0
PMID | Year | Title |
|---|