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Tbio
CXCL16
C-X-C motif chemokine 16

Protein Summary
Description
Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293778
  • ENSP00000293778
  • ENSG00000161921
  • ENST00000574412
  • ENSP00000459592

Symbol
  • SCYB16
  • SRPSOX
  • SRPSOX
  • CXCLG16
  • SR-PSOX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor perturbation
0.94
PubMedID
0.84
biological term
0.82
gene perturbation
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 248.82   (req: < 5)
Gene RIFs: 131   (req: <= 3)
Antibodies: 445   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 248.82   (req: >= 5)
Gene RIFs: 131   (req: > 3)
Antibodies: 445   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (306)
CXCR6
Tchem
Family:  GPCR
Novelty:  0.00602345
Score:  0.993
Data Source:  Reactome,STRINGDB
CXCL10
Tbio
Novelty:  0.00040194
Score:  0.965
Data Source:  STRINGDB
CXCL9
Tbio
Novelty:  0.00073213
Score:  0.964
Data Source:  STRINGDB
CCL5
Tchem
Novelty:  0.00032607
Score:  0.963
Data Source:  STRINGDB
CXCL12
Tchem
Novelty:  0.00026817
Score:  0.962
Data Source:  STRINGDB
CX3CL1
Tbio
Novelty:  0.00123987
Score:  0.962
Data Source:  STRINGDB
CXCL1
Tbio
Novelty:  0.00059123
Score:  0.959
Data Source:  STRINGDB
CCL20
Tbio
Novelty:  0.00158263
Score:  0.958
Data Source:  STRINGDB
CXCL11
Tbio
Novelty:  0.00077765
Score:  0.957
Data Source:  STRINGDB
CCL25
Tbio
Novelty:  0.00824289
Score:  0.957
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
1 – 3 of 3
Pathways (12)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
3
3
94.4
sphingomyelin measurement
5
4
11
92.9
eosinophil count
5
5
6
90
lymphocyte count
4
4
6
87.2
triglyceride measurement
10
3
10
85.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
3
94.4
sphingomyelin measurement
11
92.9
eosinophil count
6
90
lymphocyte count
6
87.2
triglyceride measurement
10
85.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-X-C motif chemokine ligand 16
VGNC:9252
454451
Macaque
C-X-C motif chemokine ligand 16
721566
Mouse
MGI:1932682
66102
Rat
RGD:1562928
497942
Dog
C-X-C motif chemokine ligand 16
VGNC:53326
607514
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-X-C motif chemokine ligand 16
Macaque
C-X-C motif chemokine ligand 16
Mouse
Rat
Dog
C-X-C motif chemokine ligand 16
Publication Statistics
PubMed Score 248.82
PubMed score by year
PubTator Score 171.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title