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Tbio
CXCL14
C-X-C motif chemokine 14

Protein Summary
Description
Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays. This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337225
  • ENSP00000337065
  • ENSG00000145824

Symbol
  • MIP2G
  • NJAC
  • SCYB14
  • KEC
  • KS1
  • BMAC
  • BRAK
  • NJAC
  • MIP2G
  • MIP-2g
  • SCYB14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.98
gene perturbation
0.96
disease
0.7
phenotype
0.64
biological term
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 189.57   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 291   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 189.57   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
CTNNBL1
Tbio
Novelty:  0.0189038
p_int:  0.999312325
p_ni:  0.000684821
p_wrong:  0.000002854
Data Source:  BioPlex
ACTR10
Tbio
Novelty:  0.11388846
p_int:  0.995994164
p_ni:  0.004005836
Data Source:  BioPlex
DCTN5
Tbio
Novelty:  0.19530162
p_int:  0.990562033
p_ni:  0.009199652
p_wrong:  0.000238315
Data Source:  BioPlex
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.989954387
p_ni:  0.009668533
p_wrong:  0.000377079
Data Source:  BioPlex
AK4
Tbio
Family:  Kinase
Novelty:  0.00977619
p_int:  0.958984514
p_ni:  0.036980366
p_wrong:  0.00403512
Data Source:  BioPlex
PLS1
Tbio
Novelty:  0.00538817
p_int:  0.944135845
p_ni:  0.055672931
p_wrong:  0.000191224
Data Source:  BioPlex
RPRD1B
Tbio
Novelty:  0.0444394
p_int:  0.930613568
p_ni:  0.069385653
p_wrong:  7.78e-7
Data Source:  BioPlex
TRPM3
Tchem
Family:  IC
Novelty:  0.00647452
p_int:  0.921595851
p_ni:  0.011313884
p_wrong:  0.067090265
Data Source:  BioPlex
DCTN3
Tbio
Novelty:  0.14551388
p_int:  0.919429064
p_ni:  0.080570936
Data Source:  BioPlex
DCTN6
Tdark
Novelty:  0.30624393
p_int:  0.906212598
p_ni:  0.080170907
p_wrong:  0.013616495
Data Source:  BioPlex
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
Pathways (5)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Chemokine signaling pathway
KEGG
Cytokine-cytokine receptor interaction
KEGG
Viral protein interaction with cytokine and cytokine receptor
Name
Explore in Pharos
Explore in Source
Chemokine signaling pathway
Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-X-C motif chemokine ligand 14
VGNC:3960
471640
Macaque
C-X-C motif chemokine ligand 14
712076
Mouse
MGI:1888514
57266
Rat
RGD:1307406
306748
Dog
C-X-C motif chemokine ligand 14
VGNC:39748
610078
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-X-C motif chemokine ligand 14
Macaque
C-X-C motif chemokine ligand 14
Mouse
Rat
Dog
C-X-C motif chemokine ligand 14
Publication Statistics
PubMed Score 189.57
PubMed score by year
PubTator Score 94.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title