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Tchem
CXCL12
Stromal cell-derived factor 1

Protein Summary
Description
Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (PubMed:29301984). Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343575
  • ENSP00000339913
  • ENSG00000107562
  • ENST00000374426
  • ENSP00000363548
  • ENST00000374429
  • ENSP00000363551
  • ENST00000395793
  • ENSP00000379139
  • ENST00000395794
  • ENSP00000379140
  • ENST00000395795
  • ENSP00000379141

Symbol
  • SDF1
  • SDF1A
  • SDF1B
  • IRH
  • PBSF
  • SDF1
  • TLSF
  • TPAR1
  • SCYB12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
PubMedID
1
disease perturbation
0.9
disease
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4557.75   (req: < 5)
Gene RIFs: 1048   (req: <= 3)
Antibodies: 788   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4557.75   (req: >= 5)
Gene RIFs: 1048   (req: > 3)
Antibodies: 788   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 23
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0