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Tchem
CXCL12
Stromal cell-derived factor 1

Protein Summary
Description
Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (PubMed:29301984). Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343575
  • ENSP00000339913
  • ENSG00000107562
  • ENST00000374426
  • ENSP00000363548
  • ENST00000374429
  • ENSP00000363551
  • ENST00000395793
  • ENSP00000379139
  • ENST00000395794
  • ENSP00000379140
  • ENST00000395795
  • ENSP00000379141

Symbol
  • SDF1
  • SDF1A
  • SDF1B
  • IRH
  • PBSF
  • SDF1
  • TLSF
  • TPAR1
  • SCYB12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
PubMedID
1
disease perturbation
0.9
disease
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4169.66   (req: < 5)
Gene RIFs: 1048   (req: <= 3)
Antibodies: 788   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4169.66   (req: >= 5)
Gene RIFs: 1048   (req: > 3)
Antibodies: 788   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 23
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (581)
CXCR4
Tclin
Family:  GPCR
Novelty:  0.0002811
Score:  0.998
Data Source:  Reactome,STRINGDB
ACKR3
Tchem
Family:  GPCR
Novelty:  0.00727792
Score:  0.995
Data Source:  Reactome,STRINGDB
CCL25
Tbio
Novelty:  0.00824289
Score:  0.988
Data Source:  STRINGDB
CCL21
Tbio
Novelty:  0.00130736
Score:  0.983
Data Source:  STRINGDB
CCL20
Tbio
Novelty:  0.00158263
Score:  0.983
Data Source:  STRINGDB
CCR4
Tclin
Family:  GPCR
Novelty:  0.01074935
Score:  0.982
Data Source:  STRINGDB
CCL5
Tchem
Novelty:  0.00032607
Score:  0.981
Data Source:  STRINGDB
CXCL13
Tbio
Novelty:  0.00118688
Score:  0.976
Data Source:  STRINGDB
CXCL10
Tbio
Novelty:  0.00040194
Score:  0.976
Data Source:  STRINGDB
CCL19
Tbio
Novelty:  0.00169711
Score:  0.976
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
Pathways (36)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Developmental Biology
Reactome
ESR-mediated signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
Developmental Biology
ESR-mediated signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (54)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
5
2
1.1
90.9
neutrophil count
2
2
2
87.6
myeloid white cell count
1
1
1
82
lymphocyte count
2
3
3
80.4
leukocyte count
1
1
1
77.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
90.9
neutrophil count
2
87.6
myeloid white cell count
1
82
lymphocyte count
3
80.4
leukocyte count
1
77.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:103556
20315
Rat
RGD:3651
24772
Horse
C-X-C motif chemokine ligand 12
VGNC:16983
100049872
Cow
C-X-C motif chemokine ligand 12
VGNC:27848
613811
Pig
C-X-C motif chemokine ligand 12
494460
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
C-X-C motif chemokine ligand 12
Cow
C-X-C motif chemokine ligand 12
Pig
C-X-C motif chemokine ligand 12
Publication Statistics
PubMed Score 4169.66
PubMed score by year
PubTator Score 2101.61
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title