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Tbio
CXCL11
C-X-C motif chemokine 11

Protein Summary
Description
Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses. Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant li ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306621
  • ENSP00000306884
  • ENSG00000169248
  • ENST00000503860
  • ENSP00000425819

Symbol
  • ITAC
  • SCYB11
  • SCYB9B
  • IP9
  • H174
  • IP-9
  • b-R1
  • I-TAC
  • SCYB11
  • SCYB9B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
PubMedID
0.86
biological process
0.82
biological term
0.76
gene perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1293.21   (req: < 5)
Gene RIFs: 88   (req: <= 3)
Antibodies: 544   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1293.21   (req: >= 5)
Gene RIFs: 88   (req: > 3)
Antibodies: 544   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (335)
CXCR3
Tchem
Family:  GPCR
Novelty:  0.00100538
Score:  0.995
Data Source:  Reactome,STRINGDB
CXCL10
Tbio
Novelty:  0.00040194
Score:  0.988
Data Source:  STRINGDB
CCL20
Tbio
Novelty:  0.00158263
Score:  0.986
Data Source:  STRINGDB
CCL1
Tbio
Novelty:  0.00379626
Score:  0.985
Data Source:  STRINGDB
ACKR3
Tchem
Family:  GPCR
Novelty:  0.00727792
Score:  0.982
Data Source:  STRINGDB
CCR3
Tchem
Family:  GPCR
Novelty:  0.00197059
Score:  0.982
Data Source:  STRINGDB
CXCL9
Tbio
Novelty:  0.00073213
Score:  0.981
Data Source:  STRINGDB
CCL5
Tchem
Novelty:  0.00032607
Score:  0.981
Data Source:  STRINGDB
CXCL6
Tbio
Novelty:  0.01019922
Score:  0.98
Data Source:  STRINGDB
PPBP
Tbio
Novelty:  0.00048307
Score:  0.979
Data Source:  STRINGDB
Pathways (82)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-X-C motif chemokine 10 measurement
2
2
0
1.7
91.4
fetal genotype effect measurement
1
1
1
61.4
protein measurement
1
1
1
61.4
monokine induced by gamma interferon measurement
1
2
2
57.7
age at first birth measurement
1
1
1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-X-C motif chemokine 10 measurement
0
1.7
91.4
fetal genotype effect measurement
1
61.4
protein measurement
1
61.4
monokine induced by gamma interferon measurement
2
57.7
age at first birth measurement
1
38.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-X-C motif chemokine ligand 11
VGNC:8660
739195
Rat
RGD:727827
305236
Horse
C-X-C motif chemokine ligand 11
VGNC:16982
100629807
Cow
C-X-C motif chemokine ligand 11
VGNC:27847
516104
Pig
C-X-C motif chemokine ligand 11
100169744
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-X-C motif chemokine ligand 11
Rat
Horse
C-X-C motif chemokine ligand 11
Cow
C-X-C motif chemokine ligand 11
Pig
C-X-C motif chemokine ligand 11
Publication Statistics
PubMed Score 1293.21
PubMed score by year
PubTator Score 378.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title