Tbio CXADR Coxsackievirus and adenovirus receptor

Protein Summary

Description

Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. (Microbial infection) Acts as a receptor for adenovirus type C. (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6. The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011]

Uniprot Accession IDs

• P78310
• B2R8V8
• B7WPI3
• D3YHP0
• O00694
• Q8WWT6
• Q8WWT7
• Q8WWT8
• Q9UKV4
• CAR

Gene Name

• CXADR

Ensembl ID

• ENST00000284878
• ENSP00000284878
• ENSG00000154639
• ENST00000356275
• ENSP00000348620
• ENST00000400165
• ENSP00000383029
• ENST00000400166
• ENSP00000383030
• ENST00000400169
• ENSP00000383033

Symbol

• CAR
• CAR
• HCAR
• CAR4/6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
kinase perturbation	0.95
gene perturbation	0.93
small molecule perturbation	0.87
microRNA	0.85

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 388.99   (req: < 5)

Gene RIFs: 93   (req: <= 3)

Antibodies: 417   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 388.99   (req: >= 5)

Gene RIFs: 93   (req: > 3)

Antibodies: 417   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0