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Tchem
CX3CR1
CX3C chemokine receptor 1

Protein Summary
Description
Receptor for the CX3C chemokine fractalkine (CX3CL1); binds to CX3CL1 and mediates both its adhesive and migratory functions (PubMed:9390561, PubMed:23125415). Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro) (PubMed:9726990). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1 (PubMed:14607932). Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358309
  • ENSP00000351059
  • ENSG00000168329
  • ENST00000399220
  • ENSP00000382166
  • ENST00000541347
  • ENSP00000439140
  • ENST00000542107
  • ENSP00000444928

Symbol
  • CMKBRL1
  • GPR13
  • V28
  • CCRL1
  • GPR13
  • CMKDR1
  • GPRV28
  • CMKBRL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.97
PubMedID
0.96
biological process
0.82
phenotype
0.76
disease
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1008.42   (req: < 5)
Gene RIFs: 221   (req: <= 3)
Antibodies: 679   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1008.42   (req: >= 5)
Gene RIFs: 221   (req: > 3)
Antibodies: 679   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 43
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (369)
CX3CL1
Tbio
Novelty:  0.00123987
Score:  0.997
Data Source:  Reactome,STRINGDB
CCL5
Tchem
Novelty:  0.00032607
Score:  0.965
Data Source:  STRINGDB
CXCL12
Tchem
Novelty:  0.00026817
Score:  0.962
Data Source:  STRINGDB
CXCL10
Tbio
Novelty:  0.00040194
Score:  0.957
Data Source:  STRINGDB
CCL4
Tbio
Novelty:  0.00069278
Score:  0.956
Data Source:  STRINGDB
CXCL1
Tbio
Novelty:  0.00059123
Score:  0.955
Data Source:  STRINGDB
CXCL8
Tchem
Novelty:  0.00005958
Score:  0.951
Data Source:  STRINGDB
CXCL9
Tbio
Novelty:  0.00073213
Score:  0.949
Data Source:  STRINGDB
CCL21
Tbio
Novelty:  0.00130736
Score:  0.949
Data Source:  STRINGDB
CXCL16
Tbio
Novelty:  0.00517074
Score:  0.947
Data Source:  STRINGDB
Pathways (15)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (56)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ARUK-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
1
2
87.3
monocyte percentage of leukocytes
2
2
3
85.9
lymphocyte count
3
1
3
83.2
granulocyte percentage of myeloid white cells
1
1
1
77.1
neutrophil percentage of leukocytes
1
1
1
72
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
87.3
monocyte percentage of leukocytes
3
85.9
lymphocyte count
3
83.2
granulocyte percentage of myeloid white cells
1
77.1
neutrophil percentage of leukocytes
1
72
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-X3-C motif chemokine receptor 1
VGNC:8831
460281
Macaque
C-X3-C motif chemokine receptor 1
693926
Mouse
MGI:1333815
13051
Rat
RGD:620137
171056
Dog
C-X3-C motif chemokine receptor 1
VGNC:39746
485599
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-X3-C motif chemokine receptor 1
Macaque
C-X3-C motif chemokine receptor 1
Mouse
Rat
Dog
C-X3-C motif chemokine receptor 1
Publication Statistics
PubMed Score 1008.42
PubMed score by year
PubTator Score 442.57
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title