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Tchem
CX3CR1
CX3C chemokine receptor 1

Protein Summary
Description
Receptor for the CX3C chemokine fractalkine (CX3CL1); binds to CX3CL1 and mediates both its adhesive and migratory functions (PubMed:9390561, PubMed:23125415). Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro) (PubMed:9726990). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1 (PubMed:14607932). Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358309
  • ENSP00000351059
  • ENSG00000168329
  • ENST00000399220
  • ENSP00000382166
  • ENST00000541347
  • ENSP00000439140
  • ENST00000542107
  • ENSP00000444928

Symbol
  • CMKBRL1
  • GPR13
  • V28
  • CCRL1
  • GPR13
  • CMKDR1
  • GPRV28
  • CMKBRL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.97
PubMedID
0.96
biological process
0.82
phenotype
0.76
disease
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1178.33   (req: < 5)
Gene RIFs: 221   (req: <= 3)
Antibodies: 679   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1178.33   (req: >= 5)
Gene RIFs: 221   (req: > 3)
Antibodies: 679   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 43
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0