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Tbio
CWC22
Pre-mRNA-splicing factor CWC22 homolog

Protein Summary
Description
Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000410053
  • ENSP00000387006
  • ENSG00000163510

Symbol
  • KIAA1604
  • NCM
  • NCM
  • fSAPb
  • EIF4GL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
tissue sample
0.64
cell type or tissue
0.61
ligand (protein) perturbation
0.59
hub protein
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.27   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.27   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0